N,N-二苄基-1,4-二噁螺[4.5]-8-癸胺合成路线 （共 6 条）
反应条件
1: in 1,2-dichloro-ethane T=20°C; 2 h; Inert atmosphere; 2: With sodium tris(acetoxy)borohydride in 1,2-dichloro-ethane T=20°C; 3: With sodium hydrogencarbonate in 1,2-dichloro-ethane 0.5 h;
参考文献
ALMIRALL, S.A.; PRAT QUINONES, Maria; FONQUERNA POU, Silvia; PUIG DURAN, Carlos; LUMERAS AMADOR, Wenceslao; AIGUADE BOSCH, Jose; CATURLA JAVALOYES, Juan Francisco
Patent: WO2011/141180 A1, 2011 ;
Location in patent: Page/Page column 48-49 ;
WO 2011/141180 A1
反应条件
potassium carbonate; potassium iodide in 1-methyl-pyrrolidin-2-one T=80°C; 24 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Patent: US2011/98282 A1, 2011 ;
Location in patent: Page/Page column 36 ;
反应条件
1.1: toluene / 2 h / Reflux 1.2: 15 - 20 °C 2.1: potassium carbonate; potassium iodide / 1-methyl-pyrrolidin-2-one / 24 h / 80 °C View Scheme
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Patent: US2011/98282 A1, 2011 ;
反应条件
1.1: toluene / 2 h / Reflux 1.2: 15 - 20 °C 2.1: potassium carbonate; potassium iodide / 1-methyl-pyrrolidin-2-one / 24 h / 80 °C View Scheme
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Patent: US2011/98282 A1, 2011 ;
反应条件
hydrogen; 10 Pd(OH)2/C in ethanol T=20°C;
参考文献
CHROMA THERAPEUTICS LTD.
Patent: WO2007/129040 A1, 2007 ;
Location in patent: Page/Page column 54-55 ;
WO 2007/129040 A1
反应条件
1: With hydrogenchloride; water T=100°C; 8 h; 2: With potassium carbonate in chloroform pH=~ 8; Cooling with ice-water;
参考文献
WO2011/141180 A1, ;
Page/Page column 49 ;
WO 2011/141180 A1
