4-(2-(1-吡咯烷)乙基)硝基苯合成路线 （共 9 条）
反应条件
in methanol 3 h; Reflux;
参考文献
AFRAXIS, INC.; CAMPBELL, David; DURÓN, Sergio, G.
Patent: WO2013/43232 A2, 2013 ;
Location in patent: Paragraph 00597 ;
WO 2013/043232 A2
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C; 5 h;
参考文献
SCHERING AKTIENGESELLSCHAFT
Patent: WO2005/42505 A1, 2005 ;
Location in patent: Page/Page column 49 ;
WO 2005/042505 A1
反应条件
in acetonitrile T=20°C;
参考文献
Nersesian, Diana L.; Black, Lawrence A.; Miller, Thomas R.; Vortherms, Timothy A.; Esbenshade, Timothy A.; Hancock, Arthur A.; Cowart, Marlon D.
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 1 p. 355 - 359
反应条件
1: water / 20 °C 2: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / Reflux View Scheme
参考文献
Wang, Li; Yang, Fenyan; Yang, Xiaochun; Guan, Xianghong; Hu, Chunqi; Liu, Tao; He, Qiaojun; Yang, Bo; Hu, Yongzhou
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 1 p. 285 - 296
反应条件
1: triphenylphosphine / dichloromethane / 0 °C 2: water / 20 °C 3: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / Reflux View Scheme
参考文献
Wang, Li; Yang, Fenyan; Yang, Xiaochun; Guan, Xianghong; Hu, Chunqi; Liu, Tao; He, Qiaojun; Yang, Bo; Hu, Yongzhou
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 1 p. 285 - 296
反应条件
sodium tetrahydroborate; boron trifluoride diethyl etherate in tetrahydrofuran Reflux;
参考文献
Wang, Li; Yang, Fenyan; Yang, Xiaochun; Guan, Xianghong; Hu, Chunqi; Liu, Tao; He, Qiaojun; Yang, Bo; Hu, Yongzhou
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 1 p. 285 - 296
反应条件
1: nitric acid; sulfuric acid / dichloromethane / 4 h / 0 - 20 °C 2: potassium carbonate / dimethyl sulfoxide / 3 h / 90 °C View Scheme
参考文献
Luo, Zonghua; Liang, Liang; Sheng, Jianfei; Pang, Yanqing; Li, Jianheng; Huang, Ling; Li, Xingshu
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 4 p. 1355 - 1361
反应条件
ethanol; hydroquinone
参考文献
Dale; Buell
Journal of Organic Chemistry, 1956 , vol. 21, p. 45,47
反应条件
palladium on activated charcoal; hydrogen in methanol P=2327.23 Torr; 16 h;
参考文献
AFRAXIS, INC.; CAMPBELL, David; DURÓN, Sergio, G.
Patent: WO2013/43232 A2, 2013 ;
Location in patent: Paragraph 00598 ;
WO 2013/043232 A2
