4-(2-吡咯烷-1-乙基)-苯胺合成路线 （共 7 条）
反应条件
palladium on activated charcoal; hydrogen in methanol P=2327.23 Torr; 16 h;
参考文献
AFRAXIS, INC.; CAMPBELL, David; DURÓN, Sergio, G.
Patent: WO2013/43232 A2, 2013 ;
Location in patent: Paragraph 00598 ;
WO 2013/043232 A2
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=20°C; 1 h;
参考文献
US2009/82379 A1, ;
Page/Page column 57 ;
反应条件
1: methanol / 3 h / |Reflux 2: palladium on activated charcoal; hydrogen / methanol / 16 h / 2327.23 Torr View Scheme
参考文献
WO2013/43232 A2, ;
WO 2013/043232 A2
反应条件
1: water / 20 °C 2: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / Reflux 3: 10 palladium on activated charcoal; hydrogen / methanol View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 46, # 1 p. 285 - 296
反应条件
1: triphenylphosphine / dichloromethane / 0 °C 2: water / 20 °C 3: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / Reflux 4: 10 palladium on activated charcoal; hydrogen / methanol View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 46, # 1 p. 285 - 296
反应条件
1: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / Reflux 2: 10 palladium on activated charcoal; hydrogen / methanol View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 46, # 1 p. 285 - 296
反应条件
1: nitric acid; sulfuric acid / dichloromethane / 4 h / 0 - 20 °C 2: potassium carbonate / dimethyl sulfoxide / 3 h / 90 °C 3: 10 platinum on carbon; hydrogen / methanol / 6 h / 15514.9 Torr View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 22, # 4 p. 1355 - 1361
