3,3-二甲基-2-苯并呋喃-1(3H)-酮合成路线 （共 31 条）
反应条件
pyridine; palladium diacetate in N,N-dimethyl-formamide T=120°C; 2 h;
参考文献
Kadnikov, Dmitry V.; Larock, Richard C.
Mendeleev Communications, 2007 , vol. 17, # 2 p. 74 - 76
反应条件
hydrogenchloride; n-butyllithium in tetrahydrofuran; hexane; acetone
参考文献
Allergan, Inc.
Patent: US2004/19098 A1, 2004 ;
反应条件
N-iodo-succinimide; silver(I) acetate in acetonitrile 14 h; Heating;
参考文献
Beebe, Thomas R.; Adkins, Rick; Baldridge, Ruth; Hensley, Vivian; McMillen, Doug; et al.
Journal of Organic Chemistry, 1987 , vol. 52, # 24 p. 5472 - 5474
反应条件
copper dichloride; palladium dichloride in 1,4-dioxane T=80°C; 12 h; Title compound not separated from byproducts;
参考文献
Organic Letters, , vol. 8, # 25 p. 5829 - 5832
反应条件
1: in tetrahydrofuran T=0°C; Grignard reaction; 2: With hydrogenchloride Hydrolysis;
参考文献
Jeong, Ill-Yun; Shiro, Motoo; Nagao, Yoshimitsu
Heterocycles, 2000 , vol. 52, # 1 p. 85 - 89
反应条件
1: dibenzo-1,4-dithiin With 4,4'-di-tert-butylbiphenyl; lithium in tetrahydrofuran T=-90°C; 0.75 h; 2: acetone in tetrahydrofuran T=-90°C; 0.75 h; 3: carbon dioxide in tetrahydrofuran T=-70°C; 0.25 h;
参考文献
Yus, Miguel; Foubelo, Francisco; Ferrandez, Jose V.
Tetrahedron, 2003 , vol. 59, # 12 p. 2083 - 2092
反应条件
1: 1-bromo-2-(1-methylethenyl)benzene With n-butyllithium in diethyl ether; hexane T=0°C; 1 h; 2: carbon dioxide in diethyl ether; hexane T=0°C; 0.5 h; 3: With hydrogenchloride in diethyl ether; hexane T=20°C; 1 h;
参考文献
Kobayashi, Kazuhiro; Kozuki, Taketoshi; Fukamachi, Shuhei; Konishi, Hisatoshi
Heterocycles, 2010 , vol. 81, # 1 p. 163 - 169
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / cooling 1.2: 60 percent / hexane; tetrahydrofuran / 0.5 h / 20 °C 2.1: CuCl2 / PdCl2 / dioxane / 12 h / 80 °C View Scheme
参考文献
Organic Letters, , vol. 8, # 25 p. 5829 - 5832
反应条件
1.1: diethyl zinc; trifluoroacetic acid / CH2Cl2; hexane / 20 h / cooling 1.2: 93 percent / CH2Cl2; hexane / 0.5 h / cooling 2.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / cooling 2.2: 60 percent / hexane; tetrahydrofuran / 0.5 h / 20 °C 3.1: CuCl2 / PdCl2 / dioxane / 12 h / 80 °C View Scheme
参考文献
Organic Letters, , vol. 8, # 25 p. 5829 - 5832
反应条件
aluminium trichloride in 1,1,2,2-tetrachloroethylene 1.5 h; Heating;
参考文献
Quinn, Kevin J.; Rae, Ian D.
Australian Journal of Chemistry, 1981 , vol. 34, # 3 p. 685 - 690
