5-(4-氯苯基磺酰基)-喹唑啉-2,4-二胺合成路线 （共 5 条）
反应条件
in isobutyramide T=155°C; 7 h;
参考文献
DECODE CHEMISTRY, INC.; SINGH, Jasbir; GURNEY, Mark E.
Patent: WO2005/123724 A1, 2005 ;
Location in patent: Page/Page column 35 ;
反应条件
T=180 - 190°C; 0.5 h;
参考文献
Chan; Hong; Kuyper; Baccanari; Joyner; Tansik; Boytos; Rudolph
Journal of Medicinal Chemistry, 1995 , vol. 38, # 18 p. 3608 - 3616
反应条件
1: 90 percent / K2CO3 / dimethylformamide / 0.5 h / 0 °C 2: 91 percent / SnCl2*2H2O, conc. HCl / bis-(2-methoxy-ethyl) ether / 0.5 h / Ambient temperature 3: 75 percent / 0.5 h / 180 - 190 °C View Scheme
参考文献
Chan; Hong; Kuyper; Baccanari; Joyner; Tansik; Boytos; Rudolph
Journal of Medicinal Chemistry, 1995 , vol. 38, # 18 p. 3608 - 3616
反应条件
1: 90 percent / K2CO3 / dimethylformamide / 0.5 h / 0 °C 2: 91 percent / SnCl2*2H2O, conc. HCl / bis-(2-methoxy-ethyl) ether / 0.5 h / Ambient temperature 3: 75 percent / 0.5 h / 180 - 190 °C View Scheme
参考文献
Chan; Hong; Kuyper; Baccanari; Joyner; Tansik; Boytos; Rudolph
Journal of Medicinal Chemistry, 1995 , vol. 38, # 18 p. 3608 - 3616
反应条件
1: 91 percent / SnCl2*2H2O, conc. HCl / bis-(2-methoxy-ethyl) ether / 0.5 h / Ambient temperature 2: 75 percent / 0.5 h / 180 - 190 °C View Scheme
参考文献
Chan; Hong; Kuyper; Baccanari; Joyner; Tansik; Boytos; Rudolph
Journal of Medicinal Chemistry, 1995 , vol. 38, # 18 p. 3608 - 3616
