1-溴-2-氟-4-(三氟甲氧基)苯合成路线 （共 2 条）
反应条件
hydrogenchloride; n-butyllithium in tetrahydrofuran
参考文献
Hegde, Vidyadhar Babu; Bis, Scott Jerome; Yap, Maurice Chee Hoong; Perreault, Denise Marie; Tisdell, Francis Eugene; Dintenfass, Leonard Paul; Dripps, James Edwin; Gifford, James Michael; Guenthenspberger, Katherine Anne; Karr, Laura Lee; Schoonover, Joe Raymond
Patent: US2003/134748 A1, 2003 ;
反应条件
1: With n-butyllithium; tri-isopropoxy-borane in tetrahydrofuran; hexane; toluene
T=-78 - -20°C; 6.5 h; Inert atmosphere;
2: With hydrogenchloride in tetrahydrofuran; hexane; water; toluene
T=-20 - 20°C; 0.666667 h; Inert atmosphere;
参考文献
Kmentova, Iveta; Sutherland, Hamish S.; Palmer, Brian D.; Blaser, Adrian; Franzblau, Scott G.; Wan, Baojie; Wang, Yuehong; Ma, Zhenkun; Denny, William A.; Thompson, Andrew M.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 23 p. 8421 - 8439
