1-甲基-3-亚甲基哌啶-2-酮合成路线 （共 3 条）
反应条件
2,2'-azo-bisisobutyronitrile; tri-n-butyl-tin hydride in benzene T=90°C; P=70680 Torr; 4 h;
参考文献
Ryu, Ilhyong; Fukuyama, Takahide; Tojino, Mami; Uenoyama, Yoshitaka; Yonamine, Yuka; Terasoma, Nozomi; Matsubara, Hiroshi
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 10 p. 3780 - 3786
反应条件
1: N-methylpiperidin-2-one With sodium hydride; oxalic acid diethyl ester in diethyl ether T=35 - 40°C; Metallation; Acylation; 72 h; 2: formaldehyd in xylene T=100°C; Condensation; 1.5 h; Further stages.;
参考文献
Rigolet, Severinne; Melot, Jean Marie; Vebrel, Joel; Chiaroni, Angele; Riche, Claude
Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 7 p. 1095 - 1103
反应条件
1: 42 percent / NaH / tetrahydrofuran / 7 h / Heating 2: 90 percent / NaBH4; CaCl2 / methanol / 14 h / 20 °C 3: 59 percent / N,N-dicyclohexylcarbodiimide; CuI / toluene / 1.17 h / Heating View Scheme
参考文献
Loreto, M. Antonietta; Migliorini, Antonella; Tardella, P. Antonio; Gambacorta, Augusto
European Journal of Organic Chemistry, 2007 , # 14 p. 2365 - 2371
