N-甲基-4-哌啶甲酸甲酯合成路线 （共 23 条）
反应条件
1: concentrated H2SO4 2: methanol 3: platinum; methanol / Hydrogenation View Scheme
参考文献
Archiwum Chemji i Farmacji, , vol. 3, p. 109,113
Chem. Zentralbl., , vol. 108, # II p. 74
反应条件
diisobutylaluminium hydride in hexane T=-70°C; 2.5 h; Yield given;
参考文献
Gray, Allan P.; Platz, Robert D.; Henderson, Theresa R.; Chang, Timothy C. P.; Takahashi, Kazuyuki; Dretchen, Kenneth L.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 4 p. 807 - 814
反应条件
1: NH3; methanol 2: SOCl2; benzene 3: diethyl ether / Behandeln des Reaktionsprodukts in Benzol mit wss. Salzsaeure View Scheme
参考文献
Grob; Renk
Helvetica Chimica Acta, 1954 , vol. 37, p. 1672,1676
参考文献
Grob; Renk
Helvetica Chimica Acta, 1954 , vol. 37, p. 1672,1676
参考文献
Grob; Renk
Helvetica Chimica Acta, 1954 , vol. 37, p. 1672,1676
反应条件
1: NH3; methanol 2: SOCl2; benzene View Scheme
参考文献
Grob; Renk
Helvetica Chimica Acta, 1954 , vol. 37, p. 1672,1676
反应条件
lithium aluminium tetrahydride; diethyl ether
参考文献
Lukes et al.
Collection of Czechoslovak Chemical Communications, 1959 , vol. 24, p. 212,216
反应条件
1: NH3; methanol
2: SOCl2; benzene
3: phenyl sodium; benzene / Erwaermen der Reaktionsloesung
4: 260 - 270 °C / 13 Torr
View Scheme
参考文献
Grob; Renk
Helvetica Chimica Acta, 1954 , vol. 37, p. 1672,1676
反应条件
(i) N2H4*H2O, EtOH, (ii) /BRN= 3595135/, aq. HCl, (iii) Pb3O4, DMF; Multistep reaction;
参考文献
Yale; Losee
Journal of medicinal chemistry, 1966 , vol. 9, # 4 p. 478 - 483
反应条件
1: NH3; methanol
2: SOCl2; benzene
3: phenyl sodium; benzene / Erwaermen der Reaktionsloesung
4: 260 - 270 °C / 13 Torr
5: aqueous NaOH
View Scheme
参考文献
Grob; Renk
Helvetica Chimica Acta, 1954 , vol. 37, p. 1672,1676
