1,4-二-(2-噻吩基)-1,3-丁二炔合成路线 （共 20 条）
反应条件
1: 100 percent / KOH, H2O / methanol / 0.42 h / Ambient temperature
2: O2, CuCl, TMEDA / acetone / 4 h
View Scheme
参考文献
Neenan, Thomas X.; Whitesides, George M.
Journal of Organic Chemistry, 1988 , vol. 53, # 11 p. 2489 - 2496
反应条件
1: 1.) PPh3 / 1.) CH2Cl2, 0 deg C, 5 min, 2.) RT, 1 h
2: 68 percent / n-BuLi / diethyl ether / 1.) -78, 1 h, 2.) RT, 1 h
3: 87 percent / CuCl, N,N,N',N'-tetramethylethylenediamine, air / 1,2-dimethoxy-ethane / 1 h / 30 - 35 °C
View Scheme
参考文献
Beny, Jean-Pierre; Dhawan, Som N.; Kagan, Jacques; Sundlass, Satinder
Journal of Organic Chemistry, 1982 , vol. 47, # 11 p. 2201 - 2204
反应条件
1: 68 percent / n-BuLi / diethyl ether / 1.) -78, 1 h, 2.) RT, 1 h
2: 87 percent / CuCl, N,N,N',N'-tetramethylethylenediamine, air / 1,2-dimethoxy-ethane / 1 h / 30 - 35 °C
View Scheme
参考文献
Beny, Jean-Pierre; Dhawan, Som N.; Kagan, Jacques; Sundlass, Satinder
Journal of Organic Chemistry, 1982 , vol. 47, # 11 p. 2201 - 2204
反应条件
1: KOH / benzene / Heating
2: O2, CuCl, TMED / 1,2-dimethoxy-ethane
View Scheme
参考文献
Sarkar, Abhijit; Talwar, Satya S.
Bulletin of the Chemical Society of Japan, 1999 , vol. 72, # 4 p. 859 - 864
参考文献
Vaitiekunas; Nord
Journal of the American Chemical Society, 1954 , vol. 76, p. 2733,2735
反应条件
Behandeln der Kupfer(I)-Verbindung mit Kalium-hexacyanoferrat(III) in alkal. wss. Loesung bei 20grad;
参考文献
Vaitiekunas; Nord
Journal of the American Chemical Society, 1954 , vol. 76, p. 2733,2735
反应条件
Schuetteln des Reaktionsgemisches mit Sauerstoff;
参考文献
Vaitiekunas; Nord
Journal of the American Chemical Society, 1954 , vol. 76, p. 2733,2735
反应条件
potassium hydroxide in water; dimethyl sulfoxide
T=130°C; 1 h; Microwave irradiation;
参考文献
Klukas, Fabian; Grunwald, Alexander; Menschel, Franziska; Mueller, Thomas J. J.
Beilstein Journal of Organic Chemistry, 2014 , vol. 10, p. 672 - 679
反应条件
diethyl ether; palladium
Hydrogenation;
参考文献
Vaitiekunas; Nord
Journal of the American Chemical Society, 1954 , vol. 76, p. 2733,2735
反应条件
sodium in tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide
参考文献
Chang, Ching-Jer; Ashendel, Curtis L.; Kim, Darrick
Patent: US2003/28015 A1, 2003 ;
