5-三氟甲氧基吲哚-2,3-二酮合成路线 （共 8 条）
反应条件
1: With sulfuric acid T=70°C; 5 h; 2: With sodium carbonate in water pH=7;
参考文献
WO2012/178015 A2, ;
Page/Page column 131 ;
WO 2012/178015 A2
反应条件
sulfuric acid T=100°C;
参考文献
Mologni, Luca; Rostagno, Roberta; Brussolo, Stefania; Knowles, Phillip P.; Kjaer, Svend; Murray-Rust, Judith; Rosso, Enrico; Zambon, Alfonso; Scapozza, Leonardo; McDonald, Neil Q.; Lucchini, Vittorio; Gambacorti-Passerini, Carlo
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 4 p. 1482 - 1496
反应条件
1: NH2OH*HCl; Na2SO4; aq. conc. HCl / Heating 2: H2SO4 / 80 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 17 p. 2427 - 2430
反应条件
1: With hydrogenchloride; hydroxylamine hydrochloride; sodium sulfate 2: With sulfuric acid Further stages.;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 20 p. 5630 - 5633
反应条件
1: With hydrazine hydrate T=140°C; 4 h; 2: With hydrogenchloride; water T=20°C; pH=2; 48 h;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 18, # 4 p. 1482 - 1496
反应条件
1.1: sodium hydroxide / water / 1 h / 50 °C 1.2: 1 h / |Cooling with ice 2.1: 3 h / |Reflux View Scheme
参考文献
The University of Tokyo; Riken; NAGANO Tetsuo; OKABE Takayoshi; KOJIMA Hirotatsu; SAITO Nae; NAKANO Hirofumi; ABE Masanao; TANAKA Akiko; HONMA Teruki; YOKOYAMA Shigeyuki; TSUGANEZAWA Keiko; YUKI Hitomi
Patent: EP2565192 A1, 2013 ;
反应条件
potassium hydroxide; dihydrogen peroxide in water; acetic acid
参考文献
PFIZER LIMITED; PFIZER INC.
Patent: WO2004/74291 A1, 2004 ;
Location in patent: Page 62-63 ;
反应条件
potassium carbonate; potassium iodide in acetonitrile T=20°C;
参考文献
Bridges, Thomas M.; Marlo, Joy E.; Niswender, Colleen M.; Jones, Carrie K.; Jadhav, Satyawan B.; Gentry, Patrick R.; Plumley, Hyekyung C.; Weaver, C. David; Conn, P. Jeffrey; Lindsley, Craig W.
Journal of Medicinal Chemistry, 2009 , vol. 52, # 11 p. 3445 - 3448
