2-溴-6,7,8,9-四氢苯并-5-环庚酮合成路线 （共 6 条）
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 23 p. 7351 - 7362
反应条件
1.1: t-BuOK / dimethylsulfoxide / 0.33 h / 20 °C 1.2: 78 percent / dimethylsulfoxide / 4 h / 20 °C 2.1: 95 percent / H2 / PtO2 / ethanol / 2 h / 20 °C 3.1: 64 percent / polyphosphoric acid / 1 h / 130 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 23 p. 7351 - 7362
反应条件
1: 95 percent / H2 / PtO2 / ethanol / 2 h / 20 °C 2: 64 percent / polyphosphoric acid / 1 h / 130 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 23 p. 7351 - 7362
反应条件
hydrogen bromide; copper(I) bromide; sodium nitrite in water T=0°C; 1 h; Yield given;
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 21 p. 3482 - 3491
反应条件
1: 25percent aq. HBr / 2 h / Heating 2: CuBr, NaNO2, 48percent HBr / H2O / 1 h / 0 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 21 p. 3482 - 3491
反应条件
1: hydrogen / 5 PtS2 on carbon / ethanol / 5 h / Inert atmosphere 2: polyphosphoric acid / 8 h / 140 °C View Scheme
参考文献
WO2012/18325 A1, ;
WO 2012/018325 A1
