(4-{2-[(2-羟基-3-苯氧基丙基)氨基]乙氧基}苯氧基)乙酸合成路线 （共 13 条）
反应条件
in tetrahydrofuran; diethyl ether T=20°C; 16 h;
参考文献
Blakemore, Paul R.; Marsden, Stephen P.; Vater, Huw D.
Organic Letters, 2006 , vol. 8, # 4 p. 773 - 776
反应条件
N-hexadecyl-N,N,N-trimethylammonium bromide; palladium; triethylamine in water T=110°C; Suzuki-Miyaura Coupling; 0.5 h; Microwave irradiation;
参考文献
Civicos, Jose F.; Alonso, Diego A.; Najera, Carmen
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 14-15 p. 2771 - 2776
反应条件
in hexane T=20°C; 7 h; Molecular sieveInert atmosphereUV-irradiation;
参考文献
Ito, Kazuta; Tamashima, Hiroto; Iwasawa, Nobuharu; Kusama, Hiroyuki
Journal of the American Chemical Society, 2011 , vol. 133, # 11 p. 3716 - 3719
反应条件
1.1: toluene / 4 h / Reflux; Inert atmosphere 2.1: magnesium bis(2,2,6,6-tetramethylpiperamide) / tetrahydro-4H-pyran; hexane / 1 h / 0 °C / Reflux; Inert atmosphere 2.2: 0 - 20 °C / Inert atmosphere View Scheme
参考文献
Kawachi, Atsushi; Nagae, Saori; Onoue, Yasuhiro; Harada, Osamu; Yamamoto, Yohsuke
Chemistry - A European Journal, 2011 , vol. 17, # 29 p. 8005 - 8008
参考文献
Priestley; De Lucca, Indawati; Ghavimi, Bahman; Erickson-Viitanen, Susan; Decicco, Carl P.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 21 p. 3199 - 3202
反应条件
mercury(II) diacetate 10 min;
参考文献
Morgan, Jacqueline; Pinhey, John T.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , p. 715 - 720
反应条件
n-butyllithium in diethyl ether
参考文献
Aldrich-Boranes, Inc.
Patent: US4795821 A1, 1989 ;
反应条件
1.1: toluene / 4 h / Reflux; Inert atmosphere 2.1: magnesium bis(2,2,6,6-tetramethylpiperamide) / tetrahydrofuran / 2.53 h / 0 °C / Reflux; Inert atmosphere 2.2: 0 - 20 °C / Inert atmosphere View Scheme
参考文献
Kawachi, Atsushi; Nagae, Saori; Onoue, Yasuhiro; Harada, Osamu; Yamamoto, Yohsuke
Chemistry - A European Journal, 2011 , vol. 17, # 29 p. 8005 - 8008
反应条件
1.1: toluene / 4 h / Reflux; Inert atmosphere 2.1: magnesium bis(2,2,6,6-tetramethylpiperamide) / tetrahydro-4H-pyran; hexane / 1 h / 0 °C / Reflux; Inert atmosphere 2.2: 0 - 20 °C / Inert atmosphere View Scheme
参考文献
Kawachi, Atsushi; Nagae, Saori; Onoue, Yasuhiro; Harada, Osamu; Yamamoto, Yohsuke
Chemistry - A European Journal, 2011 , vol. 17, # 29 p. 8005 - 8008
反应条件
in diethyl ether
byproducts: LiCl, 2-propanol; 1 equiv of PhLi slowly adding to a soln. of the boronic ester at -78°C, stirring for 3 h at the same temp., 1 equiv of anhydrous HCl in ether adding, warming to room temp., stirring for 15 min; product content detd. by (11)B NMR spectrum;
参考文献
Brown, Herbert C.; Cole, Thomas E.; Srebnik, Morris
Organometallics, 1985 , vol. 4, p. 1788 - 1792
