(4-{2-[(2-羟基-3-苯氧基丙基)氨基]乙氧基}苯氧基)乙酸合成路线 （共 13 条）
反应条件
in toluene
4 h; RefluxInert atmosphere;
参考文献
Kawachi, Atsushi; Nagae, Saori; Onoue, Yasuhiro; Harada, Osamu; Yamamoto, Yohsuke
Chemistry - A European Journal, 2011 , vol. 17, # 29 p. 8005 - 8008
反应条件
copper diacetate; triethylamine in dichloromethane
T=20°C; 24 h;
参考文献
Chan, Dominic M. T.; Monaco, Kevin L.; Li, Renhua; Bonne, Damien; Clark, Charles G.; Lam, Patrick Y. S.
Tetrahedron Letters, 2003 , vol. 44, # 19 p. 3863 - 3865
反应条件
1: 4,4'-(oxybis(methylene))bis(bromobenzene) With sec.-butyllithium in diethyl ether
T=-78°C;
2: diisopropyl phenylboronate in diethyl ether
T=-78 - 20°C;
3: With hydrogenchloride; water in diethyl ether
参考文献
Suzuki, Akinobu Z.; Ozaki, Shoichiro; Goto, Jun-Ichi; Mikoshiba, Katsuhiko
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 4 p. 1395 - 1398
