(3-溴苯基)-(6-硝基喹唑啉-4-基)胺合成路线 （共 15 条）
反应条件
in acetic acid T=148°C; 1.5 h;
参考文献
Wyeth Holdings Corporation
Patent: EP1000039 B1, 2004 ;
Location in patent: Page 34 ;
反应条件
acetic acid 2 h; Heating;
参考文献
Michalczyk, Anja; Klueter, Sabine; Rode, Haridas B.; Simard, Jeffrey R.; Gruetter, Christian; Rabiller, Matthias; Rauh, Daniel
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 7 p. 3482 - 3488
反应条件
in ethanol 1.5 h; Heating / reflux;
参考文献
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM
Patent: WO2004/13091 A2, 2004 ;
Location in patent: Page 65 ;
WO 2004/013091 A2
反应条件
1: 95 percent / 1.5 h / Heating 2: 86 percent / acetic acid / 1 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 12 p. 3544 - 3552
反应条件
1: 80 percent / thionyl chloride; DMF 2: propan-2-ol / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 16 p. 5337 - 5348
反应条件
1: 80 percent / thionyl chloride; DMF 2: propan-2-ol / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 16 p. 5337 - 5348
反应条件
1: 6-nitro-4-oxoquinazoline With thionyl chloride in 1,4-dioxane Reflux; 2: 3-bromo-aniline in isopropyl alcohol T=60°C;
参考文献
Journal of Medicinal Chemistry, , vol. 55, # 5 p. 2251 - 2264
反应条件
1: 7 h / 130 °C 2: nitric acid; sulfuric acid / 0.67 h / 95 °C 3: thionyl chloride / 3 h / |Reflux 4: isopropyl alcohol / 2 h / |Reflux View Scheme
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 55, # 14 p. 477 - 483
反应条件
1: nitric acid; sulfuric acid / 0.67 h / 95 °C 2: thionyl chloride / 3 h / |Reflux 3: isopropyl alcohol / 2 h / |Reflux View Scheme
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 55, # 14 p. 477 - 483
