N4-(3-溴苯基)喹唑啉-4,6-二胺合成路线 （共 19 条）
反应条件
iron; acetic acid in ethanol 3 h; Heating;
参考文献
Tsou; Mamuya; Johnson; Reich; Gruber; Ye; Nilakantan; Shen; Discafani; DeBlanc; Davis; Koehn; Greenberger; Wang; Wissner
Journal of Medicinal Chemistry, 2001 , vol. 44, # 17 p. 2719 - 2734
反应条件
1: propan-2-ol / Heating 2: hydrazine monohydrate / Raney Ni / ethanol; H2O; propan-2-ol View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 16 p. 5337 - 5348
反应条件
in ethanol; acetic acid
反应条件
1: 80 percent / thionyl chloride; DMF 2: propan-2-ol / Heating 3: hydrazine monohydrate / Raney Ni / ethanol; H2O; propan-2-ol View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 16 p. 5337 - 5348
反应条件
1: 95 percent / 1.5 h / Heating 2: 86 percent / acetic acid / 1 h / Heating 3: 83 percent / Fe; AcOH / H2O; ethanol / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 12 p. 3544 - 3552
反应条件
1: 80 percent / thionyl chloride; DMF 2: propan-2-ol / Heating 3: hydrazine monohydrate / Raney Ni / ethanol; H2O; propan-2-ol View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 16 p. 5337 - 5348
反应条件
1: 3-bromoaniline hydrochloride / propan-2-ol / Heating 2: AcOH, Fe (powder) / ethanol; H2O / 1 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 18 p. 3482 - 3487
反应条件
1: acetic acid / 2 h / Reflux 2: iron; acetic acid / ethanol; water / 70 - 80 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 19, # 16 p. 5012 - 5022
反应条件
1: 7 h / 130 °C 2: nitric acid; sulfuric acid / 0.67 h / 95 °C 3: thionyl chloride / 3 h / |Reflux 4: isopropyl alcohol / 2 h / |Reflux 5: acetic acid; iron / ethanol; water / 1.5 h / 95 °C View Scheme
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 55, # 14 p. 477 - 483
反应条件
1: nitric acid; sulfuric acid / 0.67 h / 95 °C 2: thionyl chloride / 3 h / |Reflux 3: isopropyl alcohol / 2 h / |Reflux 4: acetic acid; iron / ethanol; water / 1.5 h / 95 °C View Scheme
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 55, # 14 p. 477 - 483
