4-(2-甲氧基-2-氧代-亚乙基)哌啶-1-羧酸叔丁酯合成路线 （共 18 条）
反应条件
1: dimethyl methoxycarbonylmethanephosphonate With sodium hydride in N,N-dimethyl-formamide T=0°C; 0.333333 h; 2: tert-butyl 4-oxo-piperidine-1-carboxylate in N,N-dimethyl-formamide T=0 - 20°C; 3.33333 h;
参考文献
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; THE CURATORS OF THE UNIVERSITY OF MISSOURI; GINSBURG, David; LARSEN, Scott D.; YESTREPSKY, Bryan; SUN, Hongmin
Patent: WO2013/166282 A2, 2013 ;
Location in patent: Page/Page column 95 ;
反应条件
in toluene T=20°C; Heating / reflux;
参考文献
Cumbre Inc.
Patent: US2006/19985 A1, 2006 ;
Location in patent: Page/Page column 55 ;
反应条件
1: dimethyl methoxycarbonylmethanephosphonate With sodium hydride in N,N-dimethyl-formamide T=0°C; 0.333333 h; 2: tert-butyl 4-oxo-piperidine-1-carboxylate in N,N-dimethyl-formamide T=20°C; 3 h;
参考文献
Bristol-Myers Squibb Company
Patent: US2007/259850 A1, 2007 ;
Location in patent: Page/Page column 79 ;
US 20070259850 A1
反应条件
hydrogenchloride; sodium hydrogencarbonate in tetrahydrofuran
参考文献
Daiichi Pharmaceutical Co., Ltd.
Patent: US6525042 B1, 2003 ;
反应条件
hydrogenchloride; sodium hydrogencarbonate in tetrahydrofuran
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1104754 A1, 2001 ;
反应条件
in toluene Heating / reflux;
参考文献
Duan, Jingwu; King, Bryan W.; Decicco, Carl; Maduskuie JR., Thomas P.; Voss, Mathew E.
Patent: US2004/72802 A1, 2004 ;
Location in patent: Page/Page column 49 ;
反应条件
1.1: sodium hydrogencarbonate; sodium chloride / tetrahydrofuran; water / 20 °C 2.1: sodium hydroxide / ethanol / 0.5 h / 20 °C 2.2: 20 °C 2.3: pH 4 View Scheme
参考文献
EP2045245 A1, ;
EP 2045245 A1
反应条件
1.1: sodium hydrogencarbonate; sodium chloride / tetrahydrofuran; water / 20 °C 2.1: sodium hydroxide / ethanol / 0.5 h / 20 °C 2.2: 20 °C 2.3: pH 4 View Scheme
参考文献
EP2045245 A1, ;
EP 2045245 A1
反应条件
1: diethyl methoxycarbonylmethyl-phosphonate With potassium hexamethylsilazane in tetrahydrofuran 2: tert-butyl 4-oxo-piperidine-1-carboxylate in tetrahydrofuran
参考文献
US2004/2504 A1, ;
Page/Page column 23-24; 26 ;
US 20040002504 A1
反应条件
ammonia in ethanol T=12°C; 80 h; A stainless steel bomb reactor;
参考文献
Duan, Jingwu; King, Bryan W.; Decicco, Carl; Maduskuie JR., Thomas P.; Voss, Mathew E.
Patent: US2004/72802 A1, 2004 ;
Location in patent: Page/Page column 49 ;
