4-(2-甲氧基-2-氧代乙基)-4-(硝基甲基)哌啶-1-羧酸叔丁酯合成路线 （共 6 条）
反应条件
N,N,N',N'-tetramethylguanidine T=20°C; 24 h; Heating / reflux;
参考文献
Cumbre Inc.
Patent: US2006/19985 A1, 2006 ;
Location in patent: Page/Page column 55 ;
反应条件
1: 94 percent / toluene / 12 h / Heating 2: 35 percent / 1,1,3,3-tetramethylguanidine / 10 h / Heating View Scheme
参考文献
Smith, Paul W.; Cooper, Anthony W. J.; Bell, Richard; Beresford, Isabel J. M.; Gore, Paul M.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 19 p. 3772 - 3779
反应条件
nitromethane; N,N,N',N'-tetramethylguanidine 10 h; Heating;
参考文献
Smith, Paul W.; Cooper, Anthony W. J.; Bell, Richard; Beresford, Isabel J. M.; Gore, Paul M.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 19 p. 3772 - 3779
反应条件
N,N,N',N'-tetramethylguanidine 10 h; Heating;
参考文献
Smith, Paul W.; Cooper, Anthony W. J.; Bell, Richard; Beresford, Isabel J. M.; Gore, Paul M.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 19 p. 3772 - 3779
反应条件
1: 81 percent / Raney Ni / ethanol; H2O / 24 h / Ambient temperature 2: 99 percent / NaH / tetrahydrofuran / 12 h / Heating View Scheme
参考文献
Smith, Paul W.; Cooper, Anthony W. J.; Bell, Richard; Beresford, Isabel J. M.; Gore, Paul M.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 19 p. 3772 - 3779
反应条件
hydrogen; nickel in ethanol P=760.051 Torr;
参考文献
Cumbre Inc.
Patent: US2006/19985 A1, 2006 ;
Location in patent: Page/Page column 55 ;
