3-氧代-2,8-二氮杂螺[4,5]癸烷-8-羧酸叔丁酯合成路线 （共 6 条）
反应条件
hydrogen; nickel in ethanol P=760.051 Torr;
参考文献
Cumbre Inc.
Patent: US2006/19985 A1, 2006 ;
Location in patent: Page/Page column 55 ;
反应条件
1: 94 percent / toluene / 12 h / Heating 2: 35 percent / 1,1,3,3-tetramethylguanidine / 10 h / Heating 3: 81 percent / Raney Ni / ethanol; H2O / 24 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 19 p. 3772 - 3779
反应条件
1: 35 percent / 1,1,3,3-tetramethylguanidine / 10 h / Heating 2: 81 percent / Raney Ni / ethanol; H2O / 24 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 19 p. 3772 - 3779
反应条件
1: potassium carbonate / dimethyl sulfoxide / 2 h / 80 - 90 °C 2: nickel; hydrogen / ethanol / 24 h / 20 °C View Scheme
反应条件
hydrogenchloride in 1,4-dioxane; dichloromethane; water
参考文献
Tai, Vincent W.-F.; Garrido, Dulce; Price, Daniel J.; Maynard, Andrew; Pouliot, Jeffrey J.; Xiong, Zhiping; Seal, John W.; Creech, Katrina L.; Kryn, Luz H.; Baughman, Todd M.; Peat, Andrew J.
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 10 p. 2288 - 2294
反应条件
sodium hydride in tetrahydrofuran 12 h; Heating;
参考文献
Smith, Paul W.; Cooper, Anthony W. J.; Bell, Richard; Beresford, Isabel J. M.; Gore, Paul M.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 19 p. 3772 - 3779
