3-氧代-2-(苯基甲基)-2,8-二氮杂螺[4.5]癸烷-8-羧酸 1,1-二甲基乙酯合成路线 （共 4 条）
反应条件
sodium hydride in tetrahydrofuran 12 h; Heating;
参考文献
Smith, Paul W.; Cooper, Anthony W. J.; Bell, Richard; Beresford, Isabel J. M.; Gore, Paul M.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 19 p. 3772 - 3779
反应条件
1: 94 percent / toluene / 12 h / Heating 2: 35 percent / 1,1,3,3-tetramethylguanidine / 10 h / Heating 3: 81 percent / Raney Ni / ethanol; H2O / 24 h / Ambient temperature 4: 99 percent / NaH / tetrahydrofuran / 12 h / Heating View Scheme
参考文献
Smith, Paul W.; Cooper, Anthony W. J.; Bell, Richard; Beresford, Isabel J. M.; Gore, Paul M.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 19 p. 3772 - 3779
反应条件
1: 35 percent / 1,1,3,3-tetramethylguanidine / 10 h / Heating 2: 81 percent / Raney Ni / ethanol; H2O / 24 h / Ambient temperature 3: 99 percent / NaH / tetrahydrofuran / 12 h / Heating View Scheme
参考文献
Smith, Paul W.; Cooper, Anthony W. J.; Bell, Richard; Beresford, Isabel J. M.; Gore, Paul M.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 19 p. 3772 - 3779
反应条件
1: 81 percent / Raney Ni / ethanol; H2O / 24 h / Ambient temperature 2: 99 percent / NaH / tetrahydrofuran / 12 h / Heating View Scheme
参考文献
Smith, Paul W.; Cooper, Anthony W. J.; Bell, Richard; Beresford, Isabel J. M.; Gore, Paul M.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 19 p. 3772 - 3779
