(2R,4R)-4-氨基-2,4-吡咯烷二甲酸合成路线 （共 14 条）
反应条件
1: thionyl chloride / 6 h / Heating 2: triethylamine / CH2Cl2 / 6 h / Heating 3: 1.) oxalyl chloride, dimethyl sulfoxide, 2.) triethylamine / 1.) CH2Cl2, -78 deg C, 30 min, 2.) CH2Cl2, from -78 deg C to RT 4: ethanol; H2O / 24 h / 55 - 60 °C 5: 64 percent / 6 N aq. HCl / 24 h / 130 °C 6: 76 percent / H2 / 20percent Pd(OH)2-C / aq. acetic acid / 10 h / 2280 Torr / Ambient temperature View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 6, # 7 p. 1641 - 1656
反应条件
hydrogenchloride 27.5 h; Heating;
参考文献
Tueckmantel, Werner; Kozikowski, Alan P.; Wang, Shaomeng; Pshenichkin, Sergey; Wroblewski, Jarda T.
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 5 p. 601 - 606
反应条件
hydrogenchloride; sodium hydroxide 1.) Et2O, RT, 1 h, 2.) THF, RT, overnight; Yield given. Multistep reaction;
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 15 p. 2990 - 3000
反应条件
1: TsOH / toluene / Heating
2: 63 percent / Et3N / CH2Cl2
3: 50 percent / 5 M aq. NaOH / methanol / Ambient temperature
View Scheme
参考文献
Tueckmantel, Werner; Kozikowski, Alan P.; Wang, Shaomeng; Pshenichkin, Sergey; Wroblewski, Jarda T.
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 5 p. 601 - 606
