p-methoxyphenyl mercaptan; potassium carbonate in dimethyl sulfoxide; acetonitrile T=20°C; 5 h; Inert atmosphere;

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere 1.2: 1 h / -78 - 20 °C / Inert atmosphere 2.1: copper(II) bis(trifluoromethanesulfonate); (-)-2,2′-isopropylidenebis[(4S)-4-phenyl-2-oxazoline] / dichloromethane / 3 h / 32 °C / Inert atmosphere; Molecular sieve 2.2: 1 h / 32 °C / Inert atmosphere 3.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere 3.2: 4 h / 20 °C / Inert atmosphere 4.1: p-methoxyphenyl mercaptan; potassium carbonate / dimethyl sulfoxide; acetonitrile / 5 h / 20 °C / Inert atmosphere View Scheme

1.1: benzo[1,3,2]dioxaborole / tetrahydrofuran / 3 h / Reflux; Inert atmosphere 1.2: 0.42 h / 20 °C / Inert atmosphere 1.3: 12 h / Reflux 2.1: copper(II) bis(trifluoromethanesulfonate); (-)-2,2′-isopropylidenebis[(4S)-4-phenyl-2-oxazoline] / dichloromethane / 1 h / 25 °C / Inert atmosphere; Molecular sieve 2.2: 1 h / 25 °C / Inert atmosphere 3.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere 3.2: 4 h / 20 °C / Inert atmosphere 4.1: p-methoxyphenyl mercaptan; potassium carbonate / dimethyl sulfoxide; acetonitrile / 5 h / 20 °C / Inert atmosphere View Scheme

1.1: benzo[1,3,2]dioxaborole / tetrahydrofuran / 3 h / Reflux; Inert atmosphere 1.2: 0.42 h / 20 °C / Inert atmosphere 1.3: 12 h / Reflux 2.1: copper(II) bis(trifluoromethanesulfonate); (-)-2,2′-isopropylidenebis[(4S)-4-phenyl-2-oxazoline] / dichloromethane / 1 h / 25 °C / Inert atmosphere; Molecular sieve 2.2: 1 h / 25 °C / Inert atmosphere 3.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere 3.2: 4 h / 20 °C / Inert atmosphere 4.1: p-methoxyphenyl mercaptan; potassium carbonate / dimethyl sulfoxide; acetonitrile / 5 h / 20 °C / Inert atmosphere View Scheme

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere 1.2: 1 h / -78 - 20 °C / Inert atmosphere 2.1: copper(II) bis(trifluoromethanesulfonate); (-)-2,2′-isopropylidenebis[(4S)-4-phenyl-2-oxazoline] / dichloromethane / 3 h / 32 °C / Inert atmosphere; Molecular sieve 2.2: 1 h / 32 °C / Inert atmosphere 3.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere 3.2: 4 h / 20 °C / Inert atmosphere 4.1: p-methoxyphenyl mercaptan; potassium carbonate / dimethyl sulfoxide; acetonitrile / 5 h / 20 °C / Inert atmosphere View Scheme