5-(三氟甲基)噻唑-2-胺合成路线 （共 5 条）
反应条件
sodium dithionite; sodium hydrogencarbonate in water; acetonitrile T=5 - 10°C; Inert atmosphere; regioselective reaction;
参考文献
Journal of Fluorine Chemistry, , vol. 133, p. 115 - 119
反应条件
sodium dithionite; disodium hydrogen phosphate dodecahydrate in water; acetonitrile T=80°C; 3 h; Autoclave; regioselective reaction;
参考文献
Journal of Fluorine Chemistry, , vol. 133, p. 115 - 119
反应条件
1: trans-3,3,3- trifluoropropenyl phenyl sulfone With tert.-butylhydroperoxide; n-butyllithium in tetrahydrofuran T=-78 - 0°C; 2 h; 2: thiourea in N,N-dimethyl-formamide T=90°C;
参考文献
WO2012/89606 A1, ;
Page/Page column 49 ;
WO 2012/089606 A1
反应条件
in N,N-dimethyl-formamide T=75°C;
参考文献
WO2010/132404 A1, ;
Page/Page column 129-130 ;
反应条件
in N,N-dimethyl-formamide T=90°C;
参考文献
Journal of Fluorine Chemistry, , vol. 73, # 1 p. 83 - 86
