2-[4-(4-氯-丁基)-苯基]-2-甲基-丙酸合成路线 （共 17 条）
反应条件
hydrogenchloride in methanol; hexane
参考文献
Merrell Pharmaceuticals Inc.
Patent: US6147216 A1, 2000 ;
反应条件
hydrogenchloride; tetraethylammonium bromide in acetonitrile Electrolysis;
参考文献
Merrell Pharmaceuticals, Inc.
Patent: US6348597 B2, 2002 ;
Location in patent: Page column 79-80 ;
反应条件
potassium permanganate; phosphoric acid in water; acetic acid T=5°C; 5.5 h;
参考文献
Merrell Pharmaceuticals Inc.
Patent: US6340761 B1, 2002 ;
Location in patent: Page column 88-89 ;
反应条件
hydrogenchloride; thionyl chloride; potassium carbonate in water; toluene
参考文献
Merrell Pharmaceuticals Inc.
Patent: US6147216 A1, 2000 ;
反应条件
AlCl3 in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; dichloromethane; water
参考文献
Merrell Pharmaceuticals Inc.
Patent: US6147216 A1, 2000 ;
反应条件
hydrogenchloride; tetrabutyl-ammonium chloride in N,N-dimethyl-formamide T=-10°C; 2.96667 h; Electrolysis;
参考文献
Merrell Pharmaceuticals Inc.
Patent: US6340761 B1, 2002 ;
Location in patent: Page column 80 ;
反应条件
trifluorormethanesulfonic acid; water in dichloromethane T=0°C; P=30003 Torr; 22 h; Product distribution / selectivity;
参考文献
SANOFI-AVENTIS DEUTSCHLAND GMBH; JENDRALLA, Heiner; BRAUN, Matthias; KORB, Gerhard
Patent: WO2006/2762 A2, 2006 ;
Location in patent: Page/Page column 46 ;
反应条件
1: carbon monoxide With copper(I) oxide; trifluorormethanesulfonic acid in water T=30°C; P=3750.38 - 45004.5 Torr; 0.5 h; 2: 1-[4-(1-hydroxy-1-methyl-ethyl)-phenyl]-4-chloro-butan-1-one With water in tetrachloromethane T=30°C; P=3750.38 - 45004.5 Torr; 4 h; Product distribution / selectivity;
参考文献
SANOFI-AVENTIS DEUTSCHLAND GMBH; JENDRALLA, Heiner; BRAUN, Matthias; KORB, Gerhard
Patent: WO2006/2762 A2, 2006 ;
Location in patent: Page/Page column 39-40 ;
反应条件
1: carbon monoxide With trifluorormethanesulfonic acid in water T=0°C; P=30003 Torr; 0.5 h; 2: 1-[4-(1-Chloro-1-methyl-ethyl)-phenyl]-4-chloro-butan-1-one With water in tetrachloromethane T=0°C; P=30003 Torr; 4 - 20 h; Product distribution / selectivity;
参考文献
SANOFI-AVENTIS DEUTSCHLAND GMBH; JENDRALLA, Heiner; BRAUN, Matthias; KORB, Gerhard
Patent: WO2006/2762 A2, 2006 ;
Location in patent: Page/Page column 52; 53 ;
参考文献
Albany Molecular Research, Inc.
Patent: US6201124 B1, 2001 ;
