2-(Boc-氨基)-5-吡啶甲醇合成路线 （共 12 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0°C; 6.5 h;
参考文献
WO2010/3048 A1, ;
Page/Page column 110 ;
WO 2010/003048 A1
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0°C; 6.5 h;
参考文献
WO2013/59587 A1, ;
Page/Page column 207 ;
反应条件
sodium hydroxide; magnesium sulfate in tetrahydrofuran; diethyl ether; water
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0°C; 1 h;
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 4 p. 602 - 617
反应条件
1: 70 percent / DMAP / 2-methyl-propan-2-ol; acetone / 20 h / 20 °C 2: 68 percent / LiAlH4 / tetrahydrofuran / 6 h View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 12, # 5 p. 1151 - 1175
反应条件
1: 79 percent / 4-(dimethylamino)pyridine / acetonitrile / 4 h / Ambient temperature 2: 1.064 g / LiAlH4 / tetrahydrofuran / 1 h / 0 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 4 p. 602 - 617
反应条件
1: 79 percent / 4-(dimethylamino)pyridine / acetonitrile / 4 h / Ambient temperature 2: 1.064 g / LiAlH4 / tetrahydrofuran / 1 h / 0 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 4 p. 602 - 617
反应条件
1.1: SOCl2 / 72 h / Heating 1.2: 97 percent / NaOH / methanol / 1 h 2.1: 70 percent / DMAP / 2-methyl-propan-2-ol; acetone / 20 h / 20 °C 3.1: 68 percent / LiAlH4 / tetrahydrofuran / 6 h View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 12, # 5 p. 1151 - 1175
反应条件
lithium aluminium tetrahydride
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 9 p. 2141 - 2145
反应条件
methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine in tetrahydrofuran T=0 - 20°C; 12.5 h;
参考文献
SIRTRIS PHARMACEUTICALS, INC.; CASAUBON, Rebecca, L.; NARAYAN, Radha; OALMANN, Christopher; VU, Chi, B.
Patent: WO2013/59587 A1, 2013 ;
Location in patent: Page/Page column 207 ;
