1.1: diisopropylethylamine / tetrahydrofuran / 0.5 h / 0 °C 1.2: 63.8 percent / tetrahydrofuran / 12 h / 0 - 20 °C 2.1: 86.5 percent / sodium hydride; 3-hydroxypropionitrile / tetrahydrofuran / -78 - 20 °C View Scheme