1,3-二甲氧基-2-丙基苯合成路线 （共 7 条）
反应条件
n-butyllithium 1.) THF, hexane, from -70 deg C to RT, 2.) THF, hexane, RT, 18 h, b) reflux, 5 h; Yield given. Multistep reaction;
参考文献
Eli Lilly and Company
Patent: US5462954 A1, 1995 ;
US 5462954 A
反应条件
n-butyllithium 1) THF, hexane, a) -25 deg C, 3 h, b) -5 deg C, 0.5 h, 2) THF, -5 deg C to rt, overnight; Yield given. Multistep reaction;
参考文献
Brown; Bersntein; Cronk; Dossett; Hebbel; Maduskuie Jr.; Shapiro; Vacek; Yee; Willard; Krell; Snyder
Journal of Medicinal Chemistry, 1989 , vol. 32, # 4 p. 807 - 826
反应条件
in hexane; water; hydrogen bromide; acetic acid; ethyl acetate
参考文献
Eli Lilly and Company
Patent: US4777299 A1, 1988 ;
反应条件
pyridine hydrochloride T=180°C; 8 h;
参考文献
Sawyer; Bach; Baker; Baldwin; Borromeo; Cockerham; Fleisch; Floreancig; Froelich; Jackson; Marder; Palkowitz; Roman; Saussy Jr.; Schmittling; Silbaugh; Spaethe; Stengel; Sofia
Journal of Medicinal Chemistry, 1995 , vol. 38, # 22 p. 4411 - 4432
反应条件
1: 95 percent / Py*HCl / 8 h / 180 °C 2: 11 percent / copper bronze, K2CO3 / pyridine / 6 h / Heating View Scheme
参考文献
Sawyer; Bach; Baker; Baldwin; Borromeo; Cockerham; Fleisch; Floreancig; Froelich; Jackson; Marder; Palkowitz; Roman; Saussy Jr.; Schmittling; Silbaugh; Spaethe; Stengel; Sofia
Journal of Medicinal Chemistry, 1995 , vol. 38, # 22 p. 4411 - 4432
反应条件
1: 70 percent / BBr3 / CH2Cl2 / 1) -30 deg C, 2.5 h, 2) -30 deg C to rt, overnight
View Scheme
参考文献
Brown; Bersntein; Cronk; Dossett; Hebbel; Maduskuie Jr.; Shapiro; Vacek; Yee; Willard; Krell; Snyder
Journal of Medicinal Chemistry, 1989 , vol. 32, # 4 p. 807 - 826
反应条件
1: 95 percent / Py*HCl / 8 h / 180 °C
2: 14 percent / copper bronze, K2CO3 / pyridine / 6 h / Heating
3: aq. NaOH / methanol / 48 h / Heating
View Scheme
参考文献
Sawyer; Bach; Baker; Baldwin; Borromeo; Cockerham; Fleisch; Floreancig; Froelich; Jackson; Marder; Palkowitz; Roman; Saussy Jr.; Schmittling; Silbaugh; Spaethe; Stengel; Sofia
Journal of Medicinal Chemistry, 1995 , vol. 38, # 22 p. 4411 - 4432
