3-(1,3-二恶烷-2-基)苯甲醛合成路线 （共 3 条）
反应条件
1: 99 percent / p-toluenesulfonic acid / toluene / 2.5 h / Heating 2: 1.) n-BuLi / 1.) hexane, THF, from -100 deg C to -78 deg C, 1 h 25 min, 2.) hexane, THF, -70 deg C, 1 h View Scheme
参考文献
Ackerley, Norman; Brewster, Andrew G.; Brown, George R.; Clarke, David S.; Foubister, Alan J.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 10 p. 1608 - 1628
反应条件
n-butyllithium 1.) hexane, THF, from -100 deg C to -78 deg C, 1 h 25 min, 2.) hexane, THF, -70 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Ackerley, Norman; Brewster, Andrew G.; Brown, George R.; Clarke, David S.; Foubister, Alan J.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 10 p. 1608 - 1628
反应条件
lithium aluminium tetrahydride in diethyl ether T=0°C; 2 h;
参考文献
Ackerley, Norman; Brewster, Andrew G.; Brown, George R.; Clarke, David S.; Foubister, Alan J.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 10 p. 1608 - 1628
