1: acetoacetic acid tert-butyl ester With potassium tert-butylate in tetrahydrofuran
T=0°C; 1 h; Inert atmosphere;
2: 4-bromo-but-1-ene With sodium iodide in tetrahydrofuran
20 h; RefluxInert atmosphere;
3: With methanol; water in water
1 h; Reflux;
参考文献
Gan, Wei; Moon, Patrick J.; Clavette, Christian; Das Neves, Nicolas; Markiewicz, Thomas; Toderian, Amy B.; Beauchemin, Andre M.
Organic Letters, 2013 , vol. 15, # 8 p. 1890 - 1893