(S)-4-苄基-2-(2-羟基乙基)哌嗪-1-羧酸叔丁酯合成路线 （共 6 条）
反应条件
in dichloromethane T=20°C; 1 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2003/82877 A1, 2003 ;
Location in patent: Page/Page column 97 ;
WO 03/082877 A1
反应条件
sodium hydrogencarbonate in tetrahydrofuran; dichloromethane
参考文献
Biomeasure, Incorporated
Patent: US6180619 B2, 2001 ;
参考文献
Merck and Co., Inc.
Patent: US5736539 A1, 1998 ;
反应条件
1: DCC / CH2Cl2 / 18 h 2: 1.) aq. HCl, 2.) aq. NaHCO3 / 1.) CHCl3 3: LiAlH4 / tetrahydrofuran / 15 h / Heating 4: CH2Cl2 / 2 h View Scheme
参考文献
Williams; Ciccarone; MacTough; Bock; Conner; Davide; Hamilton; Koblan; Kohl; Kral; Mosser; Omer; Pompliano; Rands; Schaber; Shah; Wilson; Gibbs; Graham; et al.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 7 p. 1345 - 1348
反应条件
1: LiAlH4 / tetrahydrofuran / 15 h / Heating 2: CH2Cl2 / 2 h View Scheme
参考文献
Williams; Ciccarone; MacTough; Bock; Conner; Davide; Hamilton; Koblan; Kohl; Kral; Mosser; Omer; Pompliano; Rands; Schaber; Shah; Wilson; Gibbs; Graham; et al.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 7 p. 1345 - 1348
反应条件
1: 1.) aq. HCl, 2.) aq. NaHCO3 / 1.) CHCl3 2: LiAlH4 / tetrahydrofuran / 15 h / Heating 3: CH2Cl2 / 2 h View Scheme
参考文献
Williams; Ciccarone; MacTough; Bock; Conner; Davide; Hamilton; Koblan; Kohl; Kral; Mosser; Omer; Pompliano; Rands; Schaber; Shah; Wilson; Gibbs; Graham; et al.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 7 p. 1345 - 1348
