暂无反应条件数据

1: 1) titanium tetraisopropoxide, L-(+)-diethyltartrate, molecular sieves 4A, t-butyl hydroperoxide, 2) Me2S, aq. NaF / 1) CH2Cl2, ClCH2CH2Cl, -23 deg C, 2 h, 2) r.t., 24 h 2: 1) (COCl)2/DMSO, 2) Et3N / 1) 1) CH2Cl2, -78 deg C, 30 min, 2) r.t., 1 h 3: tetrahydrofuran / 2 h / 0 °C 4: formic acid, Et3N / Pd2(dba)3CHCl3-P(OMe)3 / dioxane / 2 h / Ambient temperature; var. phosphorus ligands; var. times; var. concentrations of formic acid 5: 83 percent / H2 / 5percent Pd/C / methanol / 24 h / Ambient temperature 6: 11 percent / p-TsOH / tetrahydrofuran; H2O / 5 h / 50 °C View Scheme

暂无反应条件数据

phosphorus trichoride in pyridine

1.1: (-)-dimethyl D-tartrate; titanium tetraisopropoxide; tert-butylhydroperoxide / molecular sieves 4 Angstroem / CH2Cl2; decane / 4 h / -20 °C 2.1: 7.35 g / trimethylphosphite; triethylamine / CH2Cl2; decane / 1.5 h 3.1: 63 percent / lithium aluminum hydride / tetrahydrofuran / 0 - 20 °C 4.1: 98 percent / sodium hydride / tetrahydrofuran / 16 h / 0 - 20 °C 5.1: 98 percent / sodium bis(trimethylsilyl)amide / tetrahydrofuran / 16 h / 0 - 20 °C 6.1: hydrogen / 20percent Pd(OH)2 on carbon / CH2Cl2 / 3.5 h 7.1: 1.74 g / pyridinium chlorochromate; molecular sieves 4 Angstroem; Celite / CH2Cl2 / 1.5 h / 20 °C 8.1: pyridinium p-toluenesulfonate; MgSO4 / diethyl ether / 18 h / 20 °C 9.1: 52 percent / BF3*Et2O / diethyl ether / 3 h / -78 - -50 °C 10.1: Mg; 1,2-dibromoethane / tetrahydrofuran / 3 h / Heating 10.2: CuBr*Me2S; trimethylsilylchloride / tetrahydrofuran / 1.67 h / -78 °C 10.3: 6.9 g / tetrahydrofuran / 1 h / -78 °C 11.1: diisobutylaluminum hydride / hexane; tetrahydrofuran / 0.75 h / -78 °C 12.1: pyridinium p-toluenesulfonate / 1 h / 20 °C 13.1: 4.4 g / BF3*Et2O / CH2Cl2 / 0.5 h / -78 °C 14.1: methanol; pyridinium p-toluenesulfonate / 18 h / Heating 15.1: 1.92 g / triethylamine / CH2Cl2 / 1 h / 20 °C 16.1: hydrochloric acid / 42 h / 60 °C View Scheme

phosphorus tribromide

pyridine; hydrogenchloride; acetic anhydride in methanol; toluene