N,N-二乙基苯甲酰胺合成路线 （共 244 条）
反应条件
1: 1.) s-BuLi, TMEDA / 1.) cyclohexane, THF, -78 deg C, 1 h, 2.) THF, cyclohexane, from -78 deg C to RT, 8 h 2: 1.) CsF, 2.) p-toluenesulfonic acid / 1.) DMF, reflux, 12 h, 2.) toluene, reflux, 12 h View Scheme
参考文献
Mills, Robert J.; Taylor, Nicholas J.; Snieckus, Victor
Journal of Organic Chemistry, 1989 , vol. 54, # 18 p. 4372 - 4385
反应条件
N,N,N',N,-tetramethylethylenediamine; sec.-butyllithium 1.) THF, -78 deg C, 20 min, 2.) a) -78 deg C, b) toluene, reflux, 3 h; Yield given. Multistep reaction;
参考文献
Beak, Peter; Brown, Roger A.
Journal of Organic Chemistry, 1982 , vol. 47, # 1 p. 34 - 46
反应条件
N,N,N',N,-tetramethylethylenediamine; sec.-butyllithium 1) THF, cyclohexane, -78 deg C, 1 h, 2) to room temperature, 12 h; Yield given. Multistep reaction;
参考文献
Tetrahedron, , vol. 48, # 23 p. 4863 - 4878
反应条件
water in hexane stirring (-20°C, 1.5 h), heating to 20°C, decompn. with water; extn. of org. layer (ether), drying of extract (over MgSO4), fractionaldistn.; elem. anal.;
参考文献
Bravo-Zhivotovskii, D. A.; Pigarev, S. D.; Vyazankina, O. A.; Kalikhman, I. D.; Vyazankin, N. S.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1982 , vol. 31, # 4 p. 841 - 843
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1982 , # 4 p. 949 - 951
反应条件
water in hexane stirring (20°C, 4 h), hydrolysis; drying and fractional distn. of org. layer;
参考文献
Bravo-Zhivotovskii, D. A.; Pigarev, S. D.; Kalikhman, I. D.; Vyazankina, O. A.; Vyazankin, N. S.
Journal of Organometallic Chemistry, 1983 , vol. 248, # 1 p. 51 - 60
反应条件
1) THF, 0 deg C, 1 h, 2) 0 deg C, 3 h; Yield given. Multistep reaction;
参考文献
Kurata, Hiroyuki; Ekinaka, Tatsuya; Kawase, Takeshi; Oda, Masaji
Tetrahedron Letters, 1993 , vol. 34, # 21 p. 3445 - 3448
反应条件
sec.-butyllithium 1.) THF, -78 deg C, 5 min, 2.) -78 deg C; Yield given. Multistep reaction;
参考文献
Beak, Peter; Brown, Roger A.
Journal of Organic Chemistry, 1982 , vol. 47, # 1 p. 34 - 46
反应条件
1.1: s-BuLi; TMEDA / tetrahydrofuran; cyclohexane / 1 h / -78 °C 1.2: tetrahydrofuran; cyclohexane / -78 - 20 °C 1.3: 94 percent / aq. HCl; NH4Cl / tetrahydrofuran; cyclohexane / pH 5 - 6 2.1: 85 percent / Pd(PPh3)4; aq. Na2CO3 / 1,2-dimethoxy-ethane / Heating 3.1: 96 percent / LDA / tetrahydrofuran / 1 h / 20 °C 4.1: n-BuLi / tetrahydrofuran; hexane / 0.08 h / 0 °C 4.2: 90 percent / tetrahydrofuran; hexane / 0 - 20 °C 5.1: 68 percent / aq. HCO2H; Pd(OAc)2; Ph3P / dimethylformamide / 60 - 70 °C View Scheme
参考文献
Fu, Jian-Min; Snieckus, Victor
Canadian Journal of Chemistry, 2000 , vol. 78, # 6 p. 905 - 919
反应条件
[bis(acetoxy)iodo]benzene; [Ru(p-cymene)(MesCO2)2]; trifluoroacetic acid; trifluoroacetic anhydride T=120°C; 30 h;
参考文献
Thirunavukkarasu, Vedhagiri S.; Hubrich, Jonathan; Ackermann, Lutz
Organic Letters, 2012 , vol. 14, # 16 p. 4210 - 4213
反应条件
[Ru2(p-PriC6H4Me)2(μ-Cl)Cl]2; PhI-(OCOCF3)2 in 1,2-dichloro-ethane T=80°C; 6 h; Schlenk techniqueInert atmosphere;
参考文献
Organic Letters, , vol. 15, # 13 p. 3484 - 3486
