tert-butyl N-methyl-N-[(3S)-pyrrolidin-3-yl]carbamate合成路线 （共 6 条）
反应条件
ammonium formate; palladium on activated charcoal in ethanol 2 h; Heating;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 18 p. 4922 - 4930
反应条件
hydrogen; 5 palladium on charcoal in methanol; ethanol 2 h;
参考文献
WO2012/154274 A1, ;
Page/Page column 83 ;
WO 2012/154274 A1
反应条件
1: 100 percent / TEA / CH2Cl2 / 2 h / 20 °C 2: 76 percent / ammonium formate / Pd/C / ethanol / 2 h / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 18 p. 4922 - 4930
反应条件
1: 100 percent / TEA / CH2Cl2 / 2 h / 20 °C 2: 76 percent / ammonium formate / Pd/C / ethanol / 2 h / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 18 p. 4922 - 4930
反应条件
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 °C / Cooling with ice 2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 3 h / 0 - 20 °C 2.2: 19 h / 0 - 20 °C 3.1: hydrogen / 5 palladium on charcoal / ethanol; methanol / 2 h View Scheme
参考文献
WO2012/154274 A1, ;
WO 2012/154274 A1
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 3 h / 0 - 20 °C 1.2: 19 h / 0 - 20 °C 2.1: hydrogen / 5 palladium on charcoal / ethanol; methanol / 2 h View Scheme
参考文献
WO2012/154274 A1, ;
WO 2012/154274 A1
