反应条件
1: 1.) n-BuLi / 1.) THF, hexane, -70 deg C, 2.) THF, hexane, from -70 deg C to RT, 2.5 h 2: 100 percent / DMSO, oxalyl chloride / CH2Cl2 / 0.25 h / -55 - -50 °C 3: 91 percent / diethyl ether / 1 h / Ambient temperature 4: 1.) NaH / 1.) THF, 2.) THF, RT, 2 h 5: 76 percent / H2 / 30percent Pd/C / ethyl acetate View Scheme
参考文献
Bird; Bruneau; Crawley; Edwards; Foster; Girodeau; Kingston; McMillan
Journal of Medicinal Chemistry, 1991 , vol. 34, # 7 p. 2176 - 2186
