4-(4-氨基苯基)哌啶-1-甲酸叔丁酯合成路线 （共 14 条）
反应条件
hydrogen; palladium 10 on activated carbon in methanol P=1034.32 Torr; 1 h;
参考文献
Illig, Carl R.; Ballentine, Shelley K.; Chen, Jinsheng; Meegalla, Sanath K.; Rudolph, M. Jonathan; Wall, Mark J.; Wilson, Kenneth J.; Desjarlais, Renee L.; Manthey, Carl L.; Molloy, Christopher J.
Patent: US2008/51402 A1, 2008 ;
Location in patent: Page/Page column 41 ;
US 20080051402 A1
反应条件
hydrogen; palladium 10 on activated carbon in ethanol; N,N-dimethyl-formamide T=20°C; 24 h;
参考文献
CANCER THERAPEUTICS CRC PTY LTD; DEVLIN, Mark Graeme; STREET, Ian Philip; TONG, Warwick Bonner
Patent: WO2014/27199 A1, 2014 ;
Location in patent: Page/Page column 85-86 ;
反应条件
hydrogen; palladium over charcoal in methanol T=20°C; 1 h;
参考文献
Sankyo Company, Limited
Patent: EP1764360 A1, 2007 ;
Location in patent: Page/Page column 87; 165 ;
EP 1764360 A1
反应条件
1: 4-(4'-nitrophenyl)pyridine With hydrogenchloride; hydrogen; platinum(IV) oxide in water T=25°C; 168 h; 2: di-tert-butyl dicarbonate With triethylamine in tetrahydrofuran T=0 - 25°C;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2008/23235 A1, 2008 ;
Location in patent: Page/Page column 59-60 ;
反应条件
hydrogen; palladium on activated carbon in methanol P=4137.29 Torr; 0.333333 h;
参考文献
WO2005/120509 A1, ;
Page/Page column 74 ;
WO 2005/120509 A1
反应条件
1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate; lithium chloride / 1,4-dioxane; ethanol; water; toluene / 80 °C / Inert atmosphere 2: palladium 10 on activated carbon; hydrogen / methanol / 1 h / 1034.32 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 54, # 22 p. 7860 - 7883
反应条件
1.1: lithium diisopropyl amide / n-heptane; tetrahydrofuran; ethylbenzene / 0.5 h / -78 °C 1.2: 24.5 h / -78 - 20 °C 2.1: sodium carbonate; lithium chloride / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 4 h / 85 - 90 °C 3.1: hydrogen / palladium 10 on activated carbon / N,N-dimethyl-formamide; ethanol / 24 h / 20 °C View Scheme
参考文献
WO2012/110773 A1, ;
WO 2012/110773 A1
反应条件
in dichloromethane; palladium
反应条件
1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate; lithium chloride / 1,4-dioxane; ethanol; water; toluene / 80 °C / Inert atmosphere 2: palladium 10 on activated carbon; hydrogen / methanol / 1 h / 1034.32 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 54, # 22 p. 7860 - 7883
反应条件
1: acetic acid 2: palladium on activated charcoal; hydrogen; acetic acid / methanol View Scheme
参考文献
WO2013/43232 A2, ;
WO 2013/043232 A2
