1-Boc-4-(2-氨基苯基)哌嗪合成路线 （共 8 条）
反应条件
hydrogen; palladium on activated carbon in methanol; ethyl acetate T=20°C; 15 h;
参考文献
WO2008/54702 A1, ;
Page/Page column 116 ;
WO 2008/054702 A1
反应条件
hydrogen; nickel in ethanol
参考文献
Dyck, Brian; Parker, Jessica; Phillips, Teresa; Carter, Lee; Murphy, Brian; Summers, Robin; Hermann, Julia; Baker, Tracy; Cismowski, Mary; Saunders, John; Goodfellow, Val
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 21 p. 3793 - 3796
反应条件
1: triethylamine / CH2Cl2 2: H2 / Pd/C / ethanol / 3102.89 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 3 p. 744 - 755
反应条件
1: triethylamine / CH2Cl2 2: H2 / Pd/C / ethanol / 3102.89 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 3 p. 744 - 755
反应条件
1: 89 percent / K2CO3 / dimethylsulfoxide / 130 °C 2: 91 percent / H2 / Raney Ni / ethanol View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 21 p. 3793 - 3796
反应条件
1: 89 percent / K2CO3 / dimethylsulfoxide / 130 °C 2: 91 percent / H2 / Raney Ni / ethanol View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 21 p. 3793 - 3796
反应条件
1: With sodium hydride in N,N-dimethyl-formamide; mineral oil T=80°C; 2: With palladium on activated charcoal; hydrogen in ethanol
参考文献
WO2013/55949 A2, ;
Page/Page column 40 ;
反应条件
1: 63 percent / Et3N / CH2Cl2 2: TFA / CH2Cl2 View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 21 p. 3793 - 3796
