({(5S)-3-[(E)-{(1R,7aR)-1-[(2R,3E,5R)-5,6-二甲基-3-庚烯-2-基]-7A-甲基八氢-4H-茚-4-亚基}甲基]-2,2-二氧代-1,3,4,5,6,7-六氢-2-苯并噻吩-5-基}氧基)(二甲基)(2-甲基-2-丙yL)硅烷合成路线 （共 3 条）
170081-43-3({(5S)-3-[(E)-{(1R,7aR)-1-[(2R,3E,5R)-5,6-二甲基-3-庚烯-2-基]-7A-甲基八氢-4H-茚-4-亚基}甲基]-2,2-二氧代-1,3,4,5,6,7-六氢-2-苯并噻吩-5-基}氧基)(二甲基)(2-甲基-2-丙yL)硅烷
→
反应条件
sodium hydrogencarbonate in ethanol 1.25 h; Heating;
参考文献
Choudhry, Satish C.; Belica, Peter S.; Coffen, David L.; Focella, Antonino; Maehr, Hubert; et al.
Journal of Organic Chemistry, 1993 , vol. 58, # 6 p. 1496 - 1500
170081-43-3({(5S)-3-[(E)-{(1R,7aR)-1-[(2R,3E,5R)-5,6-二甲基-3-庚烯-2-基]-7A-甲基八氢-4H-茚-4-亚基}甲基]-2,2-二氧代-1,3,4,5,6,7-六氢-2-苯并噻吩-5-基}氧基)(二甲基)(2-甲基-2-丙yL)硅烷
→
反应条件
1: 1.) O3, 2.) NaBH4 / 1.) CH2Cl2, MeOH, -10 deg C, 2.) room temperature, 2 h 2: 71 percent / I2, PPh3, imidazole / CH2Cl2 / 1.) 5 deg C, 0.5 h, 2.) room temperature, 2.0 h 3: 92.5 percent / NaHCO3 / ethanol / 2 h / Heating 4: 73 percent / Zn, NiCl2*6H2O / pyridine / 1.) 60 deg C, 30 min, 2.) 20 deg C, 2.0 h View Scheme
参考文献
Manchand, Percy S.; Yinnikouros, George P.; Belica, Peter S.; Madan, Pradeep
Journal of Organic Chemistry, 1995 , vol. 60, # 20 p. 6574 - 6581
170081-43-3({(5S)-3-[(E)-{(1R,7aR)-1-[(2R,3E,5R)-5,6-二甲基-3-庚烯-2-基]-7A-甲基八氢-4H-茚-4-亚基}甲基]-2,2-二氧代-1,3,4,5,6,7-六氢-2-苯并噻吩-5-基}氧基)(二甲基)(2-甲基-2-丙yL)硅烷
→
反应条件
1: 94 percent / NaHCO3 / aq. ethanol / 1.25 h / Heating 2: 54.9 g / SeO2, 4-methylmorpholine N-oxide / methanol / 5.5 h / Heating 3: imidazole / CH2Cl2 / 6 h / Ambient temperature View Scheme
参考文献
Choudhry, Satish C.; Belica, Peter S.; Coffen, David L.; Focella, Antonino; Maehr, Hubert; et al.
Journal of Organic Chemistry, 1993 , vol. 58, # 6 p. 1496 - 1500
