2-叔丁基-6-甲基-二氢异喹啉-2,6(1H)-二甲酯合成路线 （共 8 条）
反应条件
triethylamine in methanol 24 h;
参考文献
JANSSEN PHARMACEUTICA N.V.
Patent: WO2008/109336 A1, 2008 ;
Location in patent: Page/Page column 39 ;
WO 2008/109336 A1
反应条件
triethylamine in methanol
参考文献
Daiichi Pharmaceutical Co., Ltd.
Patent: US6525042 B1, 2003 ;
反应条件
1: With methanol in hexane; toluene T=20°C; 1.5 h; 2: With acetic acid in methanol; hexane; toluene 0.0833333 h;
参考文献
WO2012/122340 A1, ;
Page/Page column 59-60 ;
反应条件
palladium diacetate; 1,3-bis-(diphenylphosphino)propane; triethylamine T=70°C;
参考文献
Haginoya, Noriyasu; Kobayashi, Syozo; Komoriya, Satoshi; Yoshino, Toshiharu; Suzuki, Makoto; Shimada, Takashi; Watanabe, Kengo; Hirokawa, Yumiko; Furugori, Taketoshi; Nagahara, Takayasu
Journal of Medicinal Chemistry, 2004 , vol. 47, # 21 p. 5167 - 5182
反应条件
1: 94 percent / Et3N / methanol / 3 h / 20 °C 2: 88 percent / pyridine / 0.17 h / 0 °C 3: 65 percent / Et3N; Pd(OAc)2; 1,3-bis(diphenylphosphino)propane / 70 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 21 p. 5167 - 5182
反应条件
1: 94 percent / Et3N / methanol / 3 h / 20 °C 2: 88 percent / pyridine / 0.17 h / 0 °C 3: 65 percent / Et3N; Pd(OAc)2; 1,3-bis(diphenylphosphino)propane / 70 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 21 p. 5167 - 5182
反应条件
1: 88 percent / pyridine / 0.17 h / 0 °C 2: 65 percent / Et3N; Pd(OAc)2; 1,3-bis(diphenylphosphino)propane / 70 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 21 p. 5167 - 5182
反应条件
sodium hydroxide in tetrahydrofuran; methanol 3 h; Heating;
参考文献
Haginoya, Noriyasu; Kobayashi, Syozo; Komoriya, Satoshi; Yoshino, Toshiharu; Suzuki, Makoto; Shimada, Takashi; Watanabe, Kengo; Hirokawa, Yumiko; Furugori, Taketoshi; Nagahara, Takayasu
Journal of Medicinal Chemistry, 2004 , vol. 47, # 21 p. 5167 - 5182
