N-Boc-1,2,3,4-四氢异喹啉-6-甲酸合成路线 （共 6 条）
反应条件
sodium hydroxide in tetrahydrofuran; methanol 3 h; Heating;
参考文献
Haginoya, Noriyasu; Kobayashi, Syozo; Komoriya, Satoshi; Yoshino, Toshiharu; Suzuki, Makoto; Shimada, Takashi; Watanabe, Kengo; Hirokawa, Yumiko; Furugori, Taketoshi; Nagahara, Takayasu
Journal of Medicinal Chemistry, 2004 , vol. 47, # 21 p. 5167 - 5182
反应条件
1: 94 percent / Et3N / methanol / 3 h / 20 °C 2: 88 percent / pyridine / 0.17 h / 0 °C 3: 65 percent / Et3N; Pd(OAc)2; 1,3-bis(diphenylphosphino)propane / 70 °C 4: 99 percent / aq. NaOH / methanol; tetrahydrofuran / 3 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 21 p. 5167 - 5182
反应条件
1: 94 percent / Et3N / methanol / 3 h / 20 °C 2: 88 percent / pyridine / 0.17 h / 0 °C 3: 65 percent / Et3N; Pd(OAc)2; 1,3-bis(diphenylphosphino)propane / 70 °C 4: 99 percent / aq. NaOH / methanol; tetrahydrofuran / 3 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 21 p. 5167 - 5182
反应条件
1: 88 percent / pyridine / 0.17 h / 0 °C 2: 65 percent / Et3N; Pd(OAc)2; 1,3-bis(diphenylphosphino)propane / 70 °C 3: 99 percent / aq. NaOH / methanol; tetrahydrofuran / 3 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 21 p. 5167 - 5182
反应条件
1: 65 percent / Et3N; Pd(OAc)2; 1,3-bis(diphenylphosphino)propane / 70 °C 2: 99 percent / aq. NaOH / methanol; tetrahydrofuran / 3 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 21 p. 5167 - 5182
反应条件
1: With methanol in hexane; toluene T=20°C; 1.5 h; 2: With acetic acid in methanol; hexane; toluene 0.0833333 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BRENNEMAN, Jehrod Burnett; HUBER, John D.; RAUDENBUSH, Brian Christopher; SARKO, Christopher Ronald
Patent: WO2012/122340 A1, 2012 ;
Location in patent: Page/Page column 59-60 ;
