(+)-2-氨基-N-[(1S,2S)-(2-羟基-1-甲基-2-苯基)乙基]-N-甲基乙酰胺合成路线 （共 23 条）
反应条件
hydrogenchloride in methanol T=0°C; 3 h; other solvent, reagent;
参考文献
Myers, Andrew G.; Gleason, James L.; Yoon, Taeyoung; Kung, Daniel W.
Journal of the American Chemical Society, 1997 , vol. 119, # 4 p. 656 - 673
反应条件
n-butyllithium; lithium chloride Yield given. Multistep reaction;
参考文献
Krebs, Andreas; Ludwig, Verena; Pfizer, Jose; Duerner, Gerd; Goebel, Michael W.
Chemistry - A European Journal, 2004 , vol. 10, # 2 p. 544 - 553
反应条件
1: 13.0 g / Et3N / CH2Cl2 / 1 h / 0 °C 2: 84 percent / HCl / methanol / 3 h / 0 °C / other solvent, reagent View Scheme
参考文献
Myers, Andrew G.; Gleason, James L.; Yoon, Taeyoung
Journal of the American Chemical Society, 1995 , vol. 117, # 32 p. 8488 - 8489
反应条件
1: 1.) aq. NaOH, 2.) aq. sodium bicarbonate / 1.) reflux, 2.) 1.5 h 3: 1.) n-BuLi, LiCl / 1.) THF, -78 deg C, 2.) THF, 0 deg C, 1 h 4: 1.) aq. NaOH / 1.) methanol, reflux, 24 h 5: 1.) n-BuLi, LiCl View Scheme
参考文献
Myers, Andrew G.; Gleason, James L.; Yoon, Taeyoung
Journal of the American Chemical Society, 1995 , vol. 117, # 32 p. 8488 - 8489
反应条件
1: 1.) aq. NaOH, 2.) aq. sodium bicarbonate / 1.) reflux, 2.) 3 h 3: 1.) n-BuLi, LiCl / 1.) THF, -78 deg C, 2.) THF, 0 deg C, 1 h 4: 1.) aq. NaOH / 1.) methanol, reflux, 24 h 5: 1.) n-BuLi, LiCl View Scheme
参考文献
Myers, Andrew G.; Gleason, James L.; Yoon, Taeyoung
Journal of the American Chemical Society, 1995 , vol. 117, # 32 p. 8488 - 8489
反应条件
1: 1.) LDA, LiCl, 3.) aq. NaOH, 4.) aq. sodium bicarbonate 2: 1.) n-BuLi, LiCl View Scheme
参考文献
Myers, Andrew G.; Gleason, James L.; Yoon, Taeyoung
Journal of the American Chemical Society, 1995 , vol. 117, # 32 p. 8488 - 8489
反应条件
1: 1.) aq. NaOH, 2.) aq. sodium bicarbonate / 1.) reflux, 2.) 1.5 h 3: 1.) n-BuLi, LiCl / 1.) THF, -78 deg C, 2.) THF, 0 deg C, 1 h 4: 1.) aq. NaOH / 1.) methanol, reflux, 24 h 5: 1.) n-BuLi, LiCl View Scheme
参考文献
Myers, Andrew G.; Gleason, James L.; Yoon, Taeyoung
Journal of the American Chemical Society, 1995 , vol. 117, # 32 p. 8488 - 8489
反应条件
1: 1.) aq. NaOH, 2.) aq. sodium bicarbonate / 1.) reflux, 2.) 2 h 3: 1.) n-BuLi, LiCl / 1.) THF, -78 deg C, 2.) THF, 0 deg C, 1 h 4: 1.) aq. NaOH / 1.) methanol, reflux, 24 h 5: 1.) n-BuLi, LiCl View Scheme
参考文献
Myers, Andrew G.; Gleason, James L.; Yoon, Taeyoung
Journal of the American Chemical Society, 1995 , vol. 117, # 32 p. 8488 - 8489
反应条件
1: 1.) n-BuLi, LiCl / 1.) THF, -78 deg C, 2.) THF, 0 deg C, 1 h 2: 1.) aq. NaOH / 1.) methanol, reflux, 24 h 3: 1.) n-BuLi, LiCl View Scheme
参考文献
Myers, Andrew G.; Gleason, James L.; Yoon, Taeyoung
Journal of the American Chemical Society, 1995 , vol. 117, # 32 p. 8488 - 8489
反应条件
1: 1.) aq. NaOH / 1.) methanol, reflux, 24 h 2: 1.) n-BuLi, LiCl View Scheme
参考文献
Myers, Andrew G.; Gleason, James L.; Yoon, Taeyoung
Journal of the American Chemical Society, 1995 , vol. 117, # 32 p. 8488 - 8489
