2-氨基-n-((1r,2r)-1-羟基-1-苯基-2-丙基)-n-甲基乙酰胺合成路线 （共 7 条）
反应条件
1: With lithium tert-butylate in tetrahydrofuran T=23°C; 2 h; 2: With water in tetrahydrofuran
参考文献
UNIVERSITY OF ROCHESTER; MILLER, Benjamin, L.; OFORI, Leslie, O.; GROMOVA, Anna, V.
Patent: WO2012/92367 A1, 2012 ;
Location in patent: Page/Page column 51-53 ;
反应条件
lithium methanolate; lithium chloride in tetrahydrofuran T=0°C; 7 h;
参考文献
Myers, Andrew G.; Gleason, James L.; Yoon, Taeyoung; Kung, Daniel W.
Journal of the American Chemical Society, 1997 , vol. 119, # 4 p. 656 - 673
反应条件
1: BOC-glycine; pivaloyl chloride With triethylamine in dichloromethane T=0°C; 0.5 h; 2: (1r,2r)-(-)-pseudoephedrine With triethylamine in dichloromethane T=0°C; 0.666667 h; 3: With hydrogenchloride in methanol T=0°C; 3 h; Further stages.;
参考文献
Bennacer, Bibia; Trubuil, Dominique; Rivalle, Christian; Grierson, David S.
European Journal of Organic Chemistry, 2003 , # 23 p. 4561 - 4568
反应条件
lithium diisopropyl amide in tetrahydrofuran; hexane T=-78 - 0°C; various reagent ratios; Product distribution;
参考文献
Myers, Andrew G.; Gleason, James L.; Yoon, Taeyoung; Kung, Daniel W.
Journal of the American Chemical Society, 1997 , vol. 119, # 4 p. 656 - 673
反应条件
hydrogenchloride; pivaloyl chloride; triethylamine 1) CH2Cl2, 0 deg C, 30 min, 2) CH2Cl2, 0 deg C, 45 min, 3) MeOH, H2O, 0 deg C, 3 h; Multistep reaction;
参考文献
Myers, Andrew G.; Yoon, Taeyoung; Gleason, James L.
Tetrahedron Letters, 1995 , vol. 36, # 26 p. 4555 - 4558
反应条件
1: (R,R)-(-)-pseudoephedrine glycinamide hydrate With lithium chloride; lithium hexamethyldisilazane in tetrahydrofuran T=0°C; 0.666667 h; 2: allyl bromide in tetrahydrofuran T=0°C; 1 h;
参考文献
Ryan, Shannon J.; Zhang, Yongda; Kennan, Alan J.
Organic Letters, 2005 , vol. 7, # 21 p. 4765 - 4767
反应条件
lithium chloride; lithium hexamethyldisilazane 1.) THF, 0 deg C, 20 min, 2.) 0 deg C, 1 h; Yield givenMultistep reaction. Yields of byproduct given;
参考文献
Myers, Andrew G.; Schnider, Patrick; Kwon, Soojin; Kung, Daniel W.
Journal of Organic Chemistry, 1999 , vol. 64, # 9 p. 3322 - 3327
