[1-(4-氯-苯基)-2-吡咯烷-1-乙基]-甲胺合成路线 （共 5 条）
反应条件
lithium aluminium tetrahydride in diethyl ether Heating;
参考文献
Pinna, G. A.; Gavini, E.; Cignarella, G.; Scolastico, S.; Fadda, P.
European Journal of Medicinal Chemistry, 1995 , vol. 30, # 6 p. 515 - 520
反应条件
1: 70.3 percent / 10percent aq. NaOH / 24 h / Heating 2: 76.8 percent / 4N NaOH / 0.33 h / Ambient temperature 3: 1.) N,N'-carbonyldiimidazole / 1.) DMF, 40-45 deg C, 10 min, 2.) DMF, 20 deg C, 30 min 4: 88 percent / LAH / diethyl ether / Heating View Scheme
参考文献
Pinna, G. A.; Gavini, E.; Cignarella, G.; Scolastico, S.; Fadda, P.
European Journal of Medicinal Chemistry, 1995 , vol. 30, # 6 p. 515 - 520
反应条件
1: 76.8 percent / 4N NaOH / 0.33 h / Ambient temperature 2: 1.) N,N'-carbonyldiimidazole / 1.) DMF, 40-45 deg C, 10 min, 2.) DMF, 20 deg C, 30 min 3: 88 percent / LAH / diethyl ether / Heating View Scheme
参考文献
Pinna, G. A.; Gavini, E.; Cignarella, G.; Scolastico, S.; Fadda, P.
European Journal of Medicinal Chemistry, 1995 , vol. 30, # 6 p. 515 - 520
反应条件
1: 72.5 percent / ethanol; H2O / 12 h / 60 °C 2: 70.3 percent / 10percent aq. NaOH / 24 h / Heating 3: 76.8 percent / 4N NaOH / 0.33 h / Ambient temperature 4: 1.) N,N'-carbonyldiimidazole / 1.) DMF, 40-45 deg C, 10 min, 2.) DMF, 20 deg C, 30 min 5: 88 percent / LAH / diethyl ether / Heating View Scheme
参考文献
Pinna, G. A.; Gavini, E.; Cignarella, G.; Scolastico, S.; Fadda, P.
European Journal of Medicinal Chemistry, 1995 , vol. 30, # 6 p. 515 - 520
反应条件
1: 1.) N,N'-carbonyldiimidazole / 1.) DMF, 40-45 deg C, 10 min, 2.) DMF, 20 deg C, 30 min 2: 88 percent / LAH / diethyl ether / Heating View Scheme
参考文献
Pinna, G. A.; Gavini, E.; Cignarella, G.; Scolastico, S.; Fadda, P.
European Journal of Medicinal Chemistry, 1995 , vol. 30, # 6 p. 515 - 520
