N-苄基吡咯烷-3-甲酸甲酯合成路线 （共 27 条）
反应条件
1: 92 percent / H2 / 10 wt percent Pd/C / ethyl acetate 2: 85 percent / 2N NaOH / methanol / 20 °C View Scheme
参考文献
Murphy, John A.; Tripoli, Regis; Khan, Tanweer A.; Mali, Umesh W.
Organic Letters, 2005 , vol. 7, # 15 p. 3287 - 3289
反应条件
1: in tetrahydrofuran; diethyl ether T=0 - 20°C; 2: With ammonium chloride in tetrahydrofuran; diethyl ether T=0°C;
参考文献
AMGEN INC.
Patent: US2010/160280 A1, 2010 ;
Location in patent: Page/Page column 60 ;
反应条件
1: 1.) LDA, N,N,N1,N1-tetramethylethylenediamine (TMEDA) / 1.) Et2O, hexane, -65 deg C, 0.25 h, 2.) Et2O, hexane, a) from -65 deg C to RT, 2 h, b) reflux, 30 min 2: HBr (gas) / 84 h / Ambient temperature 3: aq. K2CO3 / 0.17 h 4: H2 / 10percent Pd/C / ethanol / 40 °C / 760 Torr View Scheme
参考文献
Orlek; Wadsworth; Wyman; King
Tetrahedron Letters, 1991 , vol. 32, # 9 p. 1245 - 1246
反应条件
N,N,N',N,-tetramethylethylenediamine; lithium diisopropyl amide 1.) Et2O, hexane, -65 deg C, 0.25 h, 2.) Et2O, hexane, a) from -65 deg C to RT, 2 h, b) reflux, 30 min; Yield given. Multistep reaction;
参考文献
Orlek, Barry S.; Blaney, Frank E.; Brown, Frank; Clark, Michael S. G.; Hadley, Michael S.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2726 - 2735
反应条件
oxirane; N,N,N',N,-tetramethylethylenediamine; lithium diisopropyl amide 1) Et2O, -65 deg C, 2) reflux; Yield given. Multistep reaction;
参考文献
Orlek; Wadsworth; Wyman; King
Tetrahedron Letters, 1991 , vol. 32, # 9 p. 1245 - 1246
反应条件
1: 1.) LDA, N,N,N1,N1-tetramethylethylenediamine (TMEDA) / 1.) Et2O, hexane, -65 deg C, 0.25 h, 2.) Et2O, hexane, a) from -65 deg C to RT, 2 h, b) reflux, 30 min
2: HBr (gas) / 84 h / Ambient temperature
3: aq. K2CO3 / 0.17 h
4: H2 / 10percent Pd/C / ethanol / 40 °C / 760 Torr
5: 6 M HCl / 10 h / Heating
6: SOCl2 / 4.5 h / Heating
View Scheme
参考文献
Orlek, Barry S.; Blaney, Frank E.; Brown, Frank; Clark, Michael S. G.; Hadley, Michael S.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2726 - 2735
反应条件
1: 92 percent / H2 / 10 wt percent Pd/C / ethyl acetate
2: 85 percent / 2N NaOH / methanol / 20 °C
View Scheme
参考文献
Murphy, John A.; Tripoli, Regis; Khan, Tanweer A.; Mali, Umesh W.
Organic Letters, 2005 , vol. 7, # 15 p. 3287 - 3289
