5-羟基吲哚啉-1-羧酸叔丁酯合成路线 （共 8 条）
反应条件
hydrogen; palladium on activated charcoal in ethanol T=20°C; 6 h;
参考文献
Igarashi; Inami; Hara; Koutoku; Oritani; Mase
Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 11 p. 1689 - 1697
反应条件
hydrogen; 10percent Pd/C in ethanol debenzylation; P=760.051 Torr;
参考文献
Stark, Lucy M.; Lin, Xiao-Fa; Flippin, Lee A.
Journal of Organic Chemistry, 2000 , vol. 65, # 10 p. 3227 - 3230
反应条件
sodium hydrogencarbonate in chloroform T=20°C; Product distribution / selectivity;
参考文献
BIOGEN IDEC MA INC.; THOMAS, Jermaine; LIU, Xiaogao; LIN, Edward, Yin-Shiang; ZHENG, Guo, Zhu; MA, Bin; CALDWELL, Richard, D.; GUCKIAN, Kevin, M.; KUMARAVEL, Gnanasambandam; TAVERAS, Arthur, G.
Patent: WO2011/17561 A1, 2011 ;
Location in patent: Page/Page column 47 ;
WO 2011/017561 A1
反应条件
in benzene T=160°C; Cycloaddition; Diels-Alder reaction; Elimination; 6 h;
参考文献
Padwa, Albert; Brodney, Michael A.; Liu, Bing; Satake, Kyosuke; Wu, Tianhua
Journal of Organic Chemistry, 1999 , vol. 64, # 10 p. 3595 - 3607
反应条件
1: 89 percent / DMAP / acetonitrile / 2 h / 20 °C 2: 96 percent / H2 / 10 percent Pd/C / ethanol / 6 h / 20 °C View Scheme
参考文献
Stark, Lucy M.; Lin, Xiao-Fa; Flippin, Lee A.
Journal of Organic Chemistry, 2000 , vol. 65, # 10 p. 3227 - 3230
反应条件
1: tetrahydrofuran / 20 °C 2: 90 percent / H2 / 10percent Pd/C / ethanol / 760.05 Torr View Scheme
参考文献
Stark, Lucy M.; Lin, Xiao-Fa; Flippin, Lee A.
Journal of Organic Chemistry, 2000 , vol. 65, # 10 p. 3227 - 3230
反应条件
1: 89 percent / DMAP / acetonitrile / 2 h / 20 °C 2: 96 percent / H2 / 10 percent Pd/C / ethanol / 6 h / 20 °C View Scheme
参考文献
Igarashi; Inami; Hara; Koutoku; Oritani; Mase
Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 11 p. 1689 - 1697
反应条件
hydrogenchloride in 1,4-dioxane
T=20°C; 3 h;
参考文献
Daiichi Sankyo Company, Limited
Patent: EP2017263 A1, 2009 ;
Location in patent: Page/Page column 109 ;
EP 2017263 A1
