4-[(1E)-7-甲基-3-乙烯基-1,6-辛二烯-1-基]苯酚合成路线 （共 14 条）
反应条件
methyl-magnesium iodide T=160°C; 0.166667 h;
参考文献
Esumi, Tomoyuki; Yamamoto, Chihiro; Fukuyama, Yoshiyasu
Synlett, 2013 , vol. 24, # 14 art. no. ST-2013-U0439-L, p. 1845 - 1847
反应条件
1: With methyl-magnesium iodide in diethyl ether 2: T=185°C; 0.166667 h; Inert atmosphere; optical yield given as percent ee;
参考文献
Du, Xiao-Long; Chen, Hong-Li; Feng, Hui-Jin; Li, Yuan-Chao
Helvetica Chimica Acta, 2008 , vol. 91, # 2 p. 371 - 378
反应条件
1: With methyl-magnesium iodide in diethyl ether 2: T=185°C; 0.166667 h; Inert atmosphere; optical yield given as percent ee;
参考文献
Du, Xiao-Long; Chen, Hong-Li; Feng, Hui-Jin; Li, Yuan-Chao
Helvetica Chimica Acta, 2008 , vol. 91, # 2 p. 371 - 378
反应条件
1: diethyl ether / 2 h / 0 °C / |Inert atmosphere 2: pyridine; trichlorophosphate / 4 h / |Inert atmosphere; |Reflux 3: methyl-magnesium iodide / diethyl ether / 0.25 h / 0 - 180 °C / |Inert atmosphere View Scheme
参考文献
Takao, Ken-Ichi; Shu, Sakamoto; Touati, Marianne Ayaka; Kusakawa, Yusuke; Tadano, Kin-Ichi
Molecules, 2012 , vol. 17, # 11 p. 13330 - 13344
反应条件
1: diethyl ether / 2 h / 0 °C / |Inert atmosphere 2: pyridine; trichlorophosphate / 4 h / |Inert atmosphere; |Reflux 3: methyl-magnesium iodide / diethyl ether / 0.25 h / 0 - 180 °C / |Inert atmosphere View Scheme
参考文献
Takao, Ken-Ichi; Shu, Sakamoto; Touati, Marianne Ayaka; Kusakawa, Yusuke; Tadano, Kin-Ichi
Molecules, 2012 , vol. 17, # 11 p. 13330 - 13344
反应条件
1: lithium chloride 2: diethyl ether / -50 °C 3: hexamethyldisilazane / tetrahydrofuran / -78 °C 4: methyl-magnesium iodide / 0.17 h / 160 °C View Scheme
参考文献
Esumi, Tomoyuki; Yamamoto, Chihiro; Fukuyama, Yoshiyasu
Synlett, 2013 , vol. 24, # 14 art. no. ST-2013-U0439-L, p. 1845 - 1847
反应条件
1: triethylamine; pivaloyl chloride / tetrahydrofuran / -25 - -20 °C 2: lithium chloride 3: diethyl ether / -50 °C 4: hexamethyldisilazane / tetrahydrofuran / -78 °C 5: methyl-magnesium iodide / 0.17 h / 160 °C View Scheme
参考文献
Esumi, Tomoyuki; Yamamoto, Chihiro; Fukuyama, Yoshiyasu
Synlett, 2013 , vol. 24, # 14 art. no. ST-2013-U0439-L, p. 1845 - 1847
反应条件
1: diethyl ether / -50 °C 2: hexamethyldisilazane / tetrahydrofuran / -78 °C 3: methyl-magnesium iodide / 0.17 h / 160 °C View Scheme
参考文献
Esumi, Tomoyuki; Yamamoto, Chihiro; Fukuyama, Yoshiyasu
Synlett, 2013 , vol. 24, # 14 art. no. ST-2013-U0439-L, p. 1845 - 1847
反应条件
1.1: n-butyllithium / hexane; tetrahydrofuran / 0.25 h / -78 °C 1.2: 0.75 h / -78 - 0 °C 2.1: sodium hexamethyldisilazane / tetrahydrofuran / -78 °C 2.2: 6 h / -50 °C 3.1: lithium borohydride / tetrahydrofuran / 0 °C 4.1: 1H-imidazole / dichloromethane / 20 °C 5.1: diisobutylaluminium hydride / dichloromethane; toluene / 3 h / -40 °C 6.1: triphenylphosphine; carbon tetrabromide / dichloromethane / 0.5 h / 20 °C / |Inert atmosphere 7.1: N,N,N',N,-tetramethylethylenediamine; anhydrous iron chloride / tetrahydrofuran / 0.5 h / 0 °C 8.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C 9.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 20 °C 10.1: tetrahydrofuran / 2.25 h / 0 - 20 °C 11.1: pyridine / 20 °C 12.1: potassium tert-butylate / dimethyl sulfoxide / 5 h / 20 °C 13.1: methyl-magnesium iodide / diethyl ether / 0.17 h / 180 °C / |Inert atmosphere View Scheme
参考文献
Xu, Qian-Qian; Zhao, Qun; Shan, Guang-Sheng; Yang, Xi-Cheng; Shi, Qi-Yuan; Lei, Xinsheng
Tetrahedron, 2013 , vol. 69, # 50 p. 10739 - 10746
反应条件
1: tetrahydrofuran / 2.25 h / 0 - 20 °C 2: pyridine / 20 °C 3: potassium tert-butylate / dimethyl sulfoxide / 5 h / 20 °C 4: methyl-magnesium iodide / diethyl ether / 0.17 h / 180 °C / |Inert atmosphere View Scheme
参考文献
Xu, Qian-Qian; Zhao, Qun; Shan, Guang-Sheng; Yang, Xi-Cheng; Shi, Qi-Yuan; Lei, Xinsheng
Tetrahedron, 2013 , vol. 69, # 50 p. 10739 - 10746
