(S)-4-异丙基-2-恶唑烷酮合成路线 （共 117 条）
参考文献
Sumitomo Pharmaceuticals Company, Limited
Patent: US5231179 A1, 1993 ;
反应条件
n-butyllithium in tetrahydrofuran; hexane -78 deg C, 30 min, -78 deg C to rt;
参考文献
Galatsis, Paul; Millan, Scott D.; Ferguson, George
Journal of Organic Chemistry, 1997 , vol. 62, # 15 p. 5048 - 5056
反应条件
n-butyllithium in tetrahydrofuran T=-78°C; 2 h;
参考文献
Tetrahedron Asymmetry, , vol. 19, # 9 p. 1068 - 1077
参考文献
Ishizuka, Tadao; Kimura, Koreichi; Ishibuchi, Seigo; Kunieda, Takehisa
Chemistry Letters, 1992 , # 6 p. 991 - 994
反应条件
n-butyllithium in tetrahydrofuran T=-78°C; 2 h;
参考文献
Tetrahedron Asymmetry, , vol. 19, # 9 p. 1068 - 1077
参考文献
Ishizuka, Tadao; Kimura, Koreichi; Ishibuchi, Seigo; Kunieda, Takehisa
Chemistry Letters, 1992 , # 6 p. 991 - 994
反应条件
n-butyllithium 1.) THF, hexane, 78 deg C, 2.) THF, hexane, 0 deg C, 30 min; Multistep reaction;
参考文献
Harding, John R.; Hughes, Rachael A.; Kelly, Nicholas M.; Sutherland, Andrew; Willis, Christine L.
Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 20 p. 3406 - 3416
反应条件
(R)-(-)-HBTM; N-ethyl-N,N-diisopropylamine in chloroform-d1 T=50°C; 3 h; Inert atmosphere;
参考文献
Perry, Matthew A.; Trinidad, Jonathan V.; Rychnovsky, Scott D.
Organic Letters, 2013 , vol. 15, # 3 p. 472 - 475
反应条件
1: (S)-4-isopropyl-oxazolidin-2-one With triethylamine; lithium chloride in tetrahydrofuran T=0°C; 0.5 h; 2: propionic acid anhydride in tetrahydrofuran T=0 - 20°C; 1.5 - 2 h;
参考文献
DAEWOONG PHARMACEUTICAL CO., LTD.; DAEWOONG CHEMICAL CO., LTD.
Patent: WO2008/127070 A1, 2008 ;
Location in patent: Page/Page column 13-14 ;
反应条件
n-butyllithium in tetrahydrofuran; hexane 1.) -78 deg C, 15 min, 2.) -78 deg C, 30 min;
参考文献
Cai, Xiaoqing; Zaleski, Paul A.; Cagir, Ali; Hecht, Sidney M.
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 12 p. 3831 - 3844
