(S)-4-异丙基-2-恶唑烷酮合成路线 （共 117 条）
反应条件
1: 1.) n-BuLi / 1.) THF, -78 deg C, 2.) THF, -78 deg C, 20 min 2: hydrazine hydrate, p-toluenesulfonic acid / ethanol / 6 h / Heating 3: NaOEt / 8 h / 95 - 125 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 111, # 6 p. 2211 - 2217
反应条件
1: With hydrogen; acetic acid; 20 palladium hydroxide on carbon T=20°C; P=75007.5 Torr; 20 h; 2: With hydrogenchloride in methanol; water Product distribution / selectivity;
参考文献
STUDIENGESELLSCHAFT KOHLE MBH
Patent: WO2005/49570 A1, 2005 ;
Location in patent: Page/Page column 13 ;
反应条件
lithium borohydride in tetrahydrofuran 1) 0 deg C, 5 min; 2) rt, 4 h;
参考文献
Journal of Organic Chemistry, , vol. 61, # 9 p. 3187 - 3190
反应条件
1: 6-((S)-4-Isopropyl-2-oxo-oxazolidin-3-yl)-pyridine-2-carbaldehyde With hydrogen; acetic acid; 20 palladium hydroxide on carbon T=20°C; P=75007.5 Torr; 20 h; 2: di-tert-butyl dicarbonate With triethylamine in dichloromethane T=0 - 20°C; 3 h; Product distribution / selectivity;
参考文献
STUDIENGESELLSCHAFT KOHLE MBH
Patent: WO2005/49570 A1, 2005 ;
Location in patent: Page/Page column 12 ;
反应条件
carbonic acid dimethyl ester T=20°C; 1 h;
参考文献
Kanomata, Nobuhiro; Maruyama, Satoshi; Tomono, Katsuhito; Anada, Shinnosuke
Tetrahedron Letters, 2003 , vol. 44, # 18 p. 3599 - 3603
反应条件
carbonic acid dimethyl ester T=50°C; 24 h;
参考文献
Kanomata, Nobuhiro; Maruyama, Satoshi; Tomono, Katsuhito; Anada, Shinnosuke
Tetrahedron Letters, 2003 , vol. 44, # 18 p. 3599 - 3603
反应条件
1: 80 percent / BF3*Et2O / CH2Cl2 / 9 h / cooling 2: NaBH4 / tetrahydrofuran / 18 h / 20 °C View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 43, # 25 p. 3307 - 3310
反应条件
1: 76 percent / BF3*Et2O / CH2Cl2 / 72 h / cooling 2: Sm(OTf)3 / 20 °C View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 43, # 25 p. 3307 - 3310
反应条件
1: 72 percent / SnCl4 / CH2Cl2 / -78 °C 2: NaBH4 / tetrahydrofuran; H2O / 2 h / 20 - 25 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 123, # 23 p. 5602 - 5603
反应条件
1.1: SnCl4 / CH2Cl2 / -78 °C 1.2: 67 percent / H2O / CH2Cl2 2.1: NaBH4 / tetrahydrofuran; H2O / 2 h / 20 - 25 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 123, # 23 p. 5602 - 5603
