9-苄基-2,3,4,9-四氢-1H-咔唑合成路线 （共 28 条）
反应条件
1: 56 percent / quinoline, sodium carbonate / 2-methoxy-ethanol / 0.75 h / Heating
2: acetic acid / 1 h / Heating
View Scheme
参考文献
El-Hamamy, Ahmad A.; Hill, John; Townend, John
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , p. 573 - 580
反应条件
1.1: sodium amide / tetrahydrofuran / 0.5 h / 0 - 20 °C / |Inert atmosphere
1.2: 1.5 h / 0 - 20 °C
2.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C
3.1: copper(l) iodide; potassium carbonate; N,N-dimethylethylenediamine / toluene / 24 h / 110 °C / |Schlenk technique; |Inert atmosphere
3.2: 1 h / 90 °C
View Scheme
参考文献
Zhan, Fuxu; Liang, Guangxin
Angewandte Chemie - International Edition, 2013 , vol. 52, # 4 p. 1266 - 1269
Angew. Chem., 2012 , vol. 125, # 4 p. 1304 - 1307,4
反应条件
1.1: sodium amide / tetrahydrofuran / 0.5 h / 0 - 20 °C / |Inert atmosphere
1.2: 1.5 h / 0 - 20 °C
2.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C
3.1: copper(l) iodide; potassium carbonate; N,N-dimethylethylenediamine / toluene / 24 h / 110 °C / |Schlenk technique; |Inert atmosphere
3.2: 1 h / 90 °C
View Scheme
参考文献
Zhan, Fuxu; Liang, Guangxin
Angewandte Chemie - International Edition, 2013 , vol. 52, # 4 p. 1266 - 1269
Angew. Chem., 2012 , vol. 125, # 4 p. 1304 - 1307,4
反应条件
1.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C
2.1: copper(l) iodide; potassium carbonate; N,N-dimethylethylenediamine / toluene / 24 h / 110 °C / |Schlenk technique; |Inert atmosphere
2.2: 1 h / 90 °C
View Scheme
参考文献
Zhan, Fuxu; Liang, Guangxin
Angewandte Chemie - International Edition, 2013 , vol. 52, # 4 p. 1266 - 1269
Angew. Chem., 2012 , vol. 125, # 4 p. 1304 - 1307,4
反应条件
in diethyl ether
19 h; Irradiation;
参考文献
El-Hamamy, Ahmad A.; Hill, John; Townend, John
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , p. 573 - 580
反应条件
in acetic acid
1 h; Heating;
参考文献
El-Hamamy, Ahmad A.; Hill, John; Townend, John
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , p. 573 - 580
反应条件
ammonia; sodium; iron nitrate (III)
anschl. mit Benzylchlorid;
参考文献
Nakazaki; Isoe
Nippon Kagaku Zasshi, 1955 , vol. 76, p. 1159,1167
Chem.Abstr., 1957 , p. 17877
参考文献
Kotschetkow et al.
Zhurnal Obshchei Khimii, 1956 , vol. 26, p. 3144,3147; engl. Ausg. S. 3505, 3507
反应条件
hydrogenchloride
T=180°C;
参考文献
Nakasaki et al.
Nippon Kagaku Zasshi, 1955 , vol. 76, p. 1262,1264
Chem.Abstr., 1957 , p. 17878
参考文献
Nakasaki et al.
Nippon Kagaku Zasshi, 1955 , vol. 76, p. 1262,1264
Chem.Abstr., 1957 , p. 17878
