1-苄基-1H-吲哚-2-羧酸合成路线 （共 13 条）
反应条件
sulfuric acid 24 h; Heating;
参考文献
Daou, Boujemaa; Soufiaoui, Mohamed
Tetrahedron, 1989 , vol. 45, # 11 p. 3351 - 3362
反应条件
sodium hydroxide in methanol
T=65°C; 2 h;
参考文献
Olgen, Sureyya; Akaho, Eiichi; Nebioglu, Dogu
European Journal of Medicinal Chemistry, 2001 , vol. 36, # 9 p. 747 - 770
反应条件
potassium hydroxide in water
1 h; Heating;
参考文献
Sechi, Mario; Derudas, Massimiliano; Dallocchio, Roberto; Dessi, Alessandro; Bacchi, Alessia; Sannia, Luciano; Carta, Fabrizio; Palomba, Michele; Ragab, Omar; Chan, Carney; Shoemaker, Robert; Sei, Shizuko; Dayam, Raveendra; Neamati, Nouri
Journal of Medicinal Chemistry, 2004 , vol. 47, # 21 p. 5298 - 5310
反应条件
1: K2CO3 / dimethylformamide
2: aq. KOH / tetrahydrofuran; ethanol / Heating
View Scheme
参考文献
Hopkins, Corey R.; O'Neil, Steven V.; Laufersweiler, Michael C.; Wang, Yili; Pokross, Matthew; Mekel, Marlene; Evdokimov, Artem; Walter, Richard; Kontoyianni, Maria; Petrey, Maria E.; Sabatakos, Georgios; Roesgen, Jeff T.; Richardson, Eloise; Demuth Jr., Thomas P.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 21 p. 5659 - 5663
反应条件
1: HCl
2: NaH
3: NaOH / methanol; H2O
View Scheme
参考文献
Lindsay, Karl B.; Ferrando, Francese; Christensen, Kasper L.; Overgaard, Jacob; Roca, Tomas; Bennasar, M.-Lluisa; Skrydstrup, Troels
Journal of Organic Chemistry, 2007 , vol. 72, # 11 p. 4181 - 4188
反应条件
1: NaH
2: NaOH / methanol; H2O
View Scheme
参考文献
Lindsay, Karl B.; Ferrando, Francese; Christensen, Kasper L.; Overgaard, Jacob; Roca, Tomas; Bennasar, M.-Lluisa; Skrydstrup, Troels
Journal of Organic Chemistry, 2007 , vol. 72, # 11 p. 4181 - 4188
反应条件
in anhydrous xylene; Petroleum ether
参考文献
Hoechst Aktiengesellschaft
Patent: US4115569 A1, 1978 ;
反应条件
1.1: KOH / dimethylsulfoxide / 20 °C
1.2: 91 percent / dimethylsulfoxide / 20 °C
2.1: 93 percent / KOH / H2O / 1 h / Heating
View Scheme
参考文献
Sechi, Mario; Derudas, Massimiliano; Dallocchio, Roberto; Dessi, Alessandro; Bacchi, Alessia; Sannia, Luciano; Carta, Fabrizio; Palomba, Michele; Ragab, Omar; Chan, Carney; Shoemaker, Robert; Sei, Shizuko; Dayam, Raveendra; Neamati, Nouri
Journal of Medicinal Chemistry, 2004 , vol. 47, # 21 p. 5298 - 5310
反应条件
hydrogenchloride
0.5 h; Heating;
参考文献
Daou, Boujemaa; Soufiaoui, Mohamed
Tetrahedron, 1989 , vol. 45, # 11 p. 3351 - 3362
反应条件
potassium hydroxide in N,N-dimethyl acetamide
T=60°C; Esterification; alkylation; 0.5 h;
参考文献
Popkov
Chemistry of Heterocyclic Compounds, 2000 , vol. 36, # 5 p. 544 - 547
