phosphate buffer; pig pancreas lipase T=20°C; pH=7.0; 72 h;

1.1: Br2 1.2: NaBH4 3.1: 38 percent / pig pancreas lipase / aq. phosphate buffer; diethyl ether / 96 h / 20 °C / pH 7 View Scheme

1: 88 percent / aq. NaBH4 / diethyl ether / 2 h / Ambient temperature 2: 68 percent / pyridine / 12 h View Scheme

2: 38 percent / pig pancreas lipase / aq. phosphate buffer; diethyl ether / 96 h / 20 °C / pH 7 View Scheme

4-(N,N-dimethlyamino)pyridine; triethylamine in dichloromethane Yield given;

1: 68 percent / pyridine / 12 h View Scheme

暂无反应条件数据

1.1: 81 percent / RuCl3*3H2O; NaIO4 / H2O; acetonitrile 2.1: 99 percent / pyridine / 12 h 3.1: 68 percent / Zn; acetic acid / diethyl ether / 12 h / Heating 4.1: RuCl3*3H2O; NaIO4 / acetonitrile; H2O 4.2: 74 percent / pyridine / 12 h 5.1: NaOMe / methanol / 12 h / 20 °C 5.2: 99 percent / aq. NaOH / 2 h / Heating View Scheme

1.1: NaOAc / H2O; acetic acid / 240 h / 125 °C 1.2: 70 percent / DMAP / CH2Cl2 2.1: 90 percent / RuCl3*3H2O; NaIO4 / H2O; acetonitrile 3.1: 83 percent / NaOMe / methanol / 12 h / 20 °C View Scheme

1.1: 80 percent / sodium / tetrahydrofuran / 13 h / 0 - 20 °C 2.1: 71 percent / aq. H2O2; trifluoroacetic anhydride; Na2CO3 / CH2Cl2 / 3 h / 20 °C 3.1: 96 percent / PPTS / acetone / 16 h / 20 °C 4.1: sodium / 24 h / 90 °C 4.2: 60 percent / aq. HCl / tetrahydrofuran / 20 °C 5.1: methanol / 10percent Pd/C / 6 h / Heating 5.2: aq. HCl / 80 °C 5.3: 85 percent / H2 / 10percent Pd/C / methanol; H2O / 12 h View Scheme