1: With isopropylmagnesium chloride in tetrahydrofuran T=-50°C; 1 h; Inert atmosphere; 2: With tri-isopropoxy-borane in tetrahydrofuran T=-40 - -10°C; Inert atmosphere; 3: With hydrogenchloride; water in tetrahydrofuran T=20°C; pH=1 - 2; Inert atmosphere;

1: 3-bromo-4-methyl-benzoic acid With n-butyllithium in tetrahydrofuran; hexane T=-100°C; 2 h; Inert atmosphere; 2: boric acid trimethyl ester in tetrahydrofuran; hexane T=-100 - 20°C; Inert atmosphere; 3: With hydrogenchloride; water in diethyl ether Inert atmosphere;

1: With sodium hydroxide; tris-(dibenzylideneacetone)dipalladium(0); 2-(dicyclohexylphosphino)-2'-methylbiphenyl in ethanol; water T=78 - 80°C; Suzuki coupling; Inert atmosphere; 2: With hydrogenchloride; water in ethanol T=20°C; pH=3.4; Inert atmosphere;

1: With tris-(dibenzylideneacetone)dipalladium(0); N,N-dicyclohexylamine; 2-(dicyclohexylphosphino)-2'-methylbiphenyl in water; butan-1-ol T=85°C; Suzuki coupling; 20 h; Inert atmosphere; 2: With sodium hydroxide in water; butan-1-ol T=60°C; 0.5 h; Inert atmosphere; 3: With hydrogenchloride; water in butan-1-ol pH=6 - 7; Inert atmosphere;

sulfuric acid in water RefluxInert atmosphere;